Issue

Vol. 33 No. 4 (2021): Vol 33 Issue 4

Copyright (c) 2021 AJC

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Bioactive Phytochemical Compounds of Physalis minima L. and its Anticholinesterase and Antioxidant Activities

https://doi.org/10.14233/ajchem.2021.23067
V. Prabhu
P.G. Department of Chemistry, Nallamuthu Gounder Mahalingam College, Pollachi-642001, India
K. Arunkumar
Faculty of Chemistry, Hindusthan Polytechnic College, Coimbatore-641032, India
B. Monika
P.G. Department of Chemistry, Nallamuthu Gounder Mahalingam College, Pollachi-642001, India
V. Latha
Department of Chemistry, Indian Academy Degree College (Autonomous), Bengaluru-560043, India
G. Sibi
Department of Biotechnology, Indian Academy Degree College (Autonomous), Bengaluru-560043, India

Corresponding Author(s) : G. Sibi

gsibii@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 4 (2021): Vol 33 Issue 4

Abstract

Physalis minima Linn. was investigated for its antioxidant and acetylcholine esterase inhibition activities. The methanolic extract of the whole plant was evaluated for radical scavenging and in vitro hydrolysis of acetylthiocholine iodide. Inhibitory concentration (IC50) of the extract exhibited IC50 values of 78.6, 46.2, 76.7 and 296 μg/mL under 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), hydroxyl radical scavenging and acetylcholine esterase inhibition assays. GC-MS analysis revealed the presence of 11 compounds of which most of the compounds were reported with biological activities. The study suggests further investigations of P. minima for isolation, purification and characterization of valuable bioactive compounds related to their radical scavenging activity and for the treatment of neurodegenerative disease.

Keywords

Physalis minima Antioxidant activity Acetylcholine esterase
Prabhu, V., Arunkumar, K., Monika, B., Latha, V., & Sibi, G. (2021). Bioactive Phytochemical Compounds of Physalis minima L. and its Anticholinesterase and Antioxidant Activities. Asian Journal of Chemistry, 33(4), 741–746. https://doi.org/10.14233/ajchem.2021.23067
Download Citation
Endnote/Zotero/Mendeley (RIS)
BibTeX
References
  1. M.I. Choudhary, Pure Appl. Chem., 73, 555 (2001);https://doi.org/10.1351/pac200173030555
  2. V. Schulz, Phytomedicine, 10, 74 (2003); https://doi.org/10.1078/1433-187X-00302
  3. M. Ashraf, K. Ahmad, I. Ahmad, S. Ahmad, S. Arshad, S.M.A. Shah and F.H. Nasim, J. Med. Plants Res., 5, 2086 (2011).
  4. A. Favier, Ann. Pharm. Fr., 64, 390 (2006); https://doi.org/10.1016/S0003-4509(06)75334-2
  5. Z. Chen, R. Bertin and G. Froldi, Food Chem., 138, 414 (2013); https://doi.org/10.1016/j.foodchem.2012.11.001
  6. B.K. Gopalkrishna, Flora of Udupi, Indian Naturalist (Regd.) Publications: Udupi, India, edn 1, p. 418 (2003).
  7. K.R. Kirtikar and B.D. Basu, Indian Medicinal Plants, Lalit Mohan Basu Publication: Allahabad, India, edn 2, p. 1766 (2003).
  8. V.V. Chi, The Dictionary of Medicinal Plant in Vietnam, Medical Publishing House: Hanoi, Vietnam, p. 929 (2012).
  9. V.C. Le Canh, V. Le Ba,P.T.H. Yen, L.L. Thi, P.T.T. Hoai, T.T.H. Dat, D.T. Thao, L.G. Bach, Y.H. Kim and H.L.T. Anh, Nat. Prod. Res., (2019); https://doi.org/10.1080/14786419.2019.1650360
  10. S.S. Wei, C.Y. Gao, R.J. Li, L.Y. Kong and J. Luo, Chin. J. Nat. Med., 17, 469 (2019).
  11. Y.Z. Guan, S.M. Shan, W. Zhang, J.G. Luo and L.Y. Kong, Steroids, 82, 38 (2014); https://doi.org/10.1016/j.steroids.2014.01.004
  12. A.K. Gupta, K.P. Shivalinge Gowda, R.N. Umashankar, R. Nandeesh and S. Sreedhar, Res. J. Pharmacol. Pharmacodyn., 5, 332 (2010).
  13. S.N. Yoganarasimhan, Medicinal Plants of India, Karnataka: Interline Publishing Pvt. Ltd., vol. 1, p. 363 (1996).
  14. K. Mohana, R. Uma and K.K. Purusothaman, Indian J. Exp. Biol., 17, 690 (1979).
  15. S. Sudhakaran, B. Ramanathan and A. Ganapathi, Pharm. Biol., 37, 269 (1999); https://doi.org/10.1076/phbi.37.4.269.5809
  16. J. Wu, X. Li, J. Zhao, R. Wang, Z. Xia, X. Li, Y. Liu, Q. Xu, I.A. Khan and S. Yang, Phytochemistry, 155, 164 (2018); https://doi.org/10.1016/j.phytochem.2018.08.009
  17. R.J. Li, C.Y. Gao, C. Guo, M.M. Zhou, J. Luo and L.Y. Kong, Inflammation, 40, 401 (2017); https://doi.org/10.1007/s10753-016-0485-1
  18. R. Lin, Y.Z. Guan, R.J. Li, X.M. Xu, J.G. Luo and L.Y. Kong, Chem.Biodivers., 13, 884 (2016); https://doi.org/10.1002/cbdv.201500282
  19. M.A. Khan, H. Khan, S. Khan, T. Mahmood, P.M. Khan and A. Jabar, J. Enzyme Inhib. Med. Chem., 24, 632 (2009); https://doi.org/10.1080/14756360802321120
  20. O.K. Leong, T.S.T. Muhammad and S.F. Sulaiman, Evid. Based Complement. Alternat. Med., 2011, 185064 (2011); https://doi.org/10.1093/ecam/nep057
  21. K.L. Ooi, T.S. Tengku Muhammad and S.F. Sulaiman, J. Ethnopharmacol., 150, 382 (2013); https://doi.org/10.1016/j.jep.2013.09.014
  22. K.L. Ooi, T.S.T. Muhammad, C.H. Lim and S.F. Sulaiman, Integr. Cancer Ther., 9, 73 (2010); https://doi.org/10.1177/1534735409356443
  23. J. Wu, T. Zhang, J. Si, Q. Xu, Y. Gu, S. Yang and Z. Zou, Fitoterapia, 140, 104413 (2020); https://doi.org/10.1016/j.fitote.2019.104413
  24. L. Ma, X.W. Gan, Q.P. He, H.Y. Bai, M. Arfan, F.C. Lou and L.H. Hu, Helv. Chim. Acta, 90, 1406 (2007); https://doi.org/10.1002/hlca.200790143
  25. N. Shrivastava, K. Shah, T. Patel and K. Jiwan, Indian J. Pharm. Sci., 73, 111 (2011); https://doi.org/10.4103/0250-474X.89770
  26. N. Shariff, M.S. Sudarshana, S. Umesha and P. Hariprasad, Afr. J. Biotechnol., 5, 946 (2006).
  27. M.I. Choudhary, S. Yousaf, S. Ahmed, S. Samreen, K. Yasmeen and Atta-ur-Rahman, Chem. Biodivers., 2, 1164 (2005); https://doi.org/10.1002/cbdv.200590086
  28. M.I. Choudhary, S. Yousuf, Samreen, S. Ahmed and Atta-Ur-Rahman, Nat. Prod. Res., 21, 877 (2007); https://doi.org/10.1080/14786410701315147
  29. D. Sathish Kumar, S.N. Raju, A. Harani, B. David, K.N. Rao and B. Otalia, Pharmacogn. J., 4, 273 (2009).
  30. N. Pellegrini, R. Ke, M. Ying and C. Rice-Evans, Methods Enzymol.,299, 379 (1999); https://doi.org/10.1016/S0076-6879(99)99037-7
  31. B. Halliwell and J.M.C. Gutteridge, Free Radicals in Biology and Medicine, Clarendon Press, vol. 3, p. 617 (1989).
  32. S. Padilla, T.L. Lassiter and D. Hunter, Methods Mol. Med., 22, 237 (1999); https://doi.org/10.1385/0-89603-612-X:237
  33. V. Lobo, A. Patil, A. Phatak and N. Chandra, Pharmacogn. Rev., 4,118 (2010); https://doi.org/10.4103/0973-7847.70902
  34. S. Chandra, S. Khan, B. Avula, H. Lata, M.H. Yang, M.A. El Sohly and I.A. Khan, Evid. Based Complement. Alternat. Med., 2014, 1 (2014); https://doi.org/10.1155/2014/253875
  35. I. Fatima, T. Hussain, M. Rafay, M. Akram, S. Bano and S. Shabbir, Pak. J. Pharm. Sci., 30, 1625 (2017).
  36. C. Scully, Dent. Update, 20, 95 (1993).
  37. N.O. Martins, I.M. de Brito, S.S.O. Araujo, G. Negri, E.A. Carlini and F.R. Mendes, BMC Complement. Altern. Med., 18, 172 (2018); https://doi.org/10.1186/s12906-018-2222-9
  38. E. Giacobini, Neurochem. Int., 32, 413 (1998); https://doi.org/10.1016/S0197-0186(97)00124-1
  39. L. Dong, A.J. Vecchio, N.P. Sharma, B.J. Jurban, M.G. Malkowski and W.L. Smith, J. Biol. Chem., 286, 19035 (2011); https://doi.org/10.1074/jbc.M111.231969
  40. L. Palakkal, N.H. Zeinul Hukuman and J. Mullappally, J. Appl. Pharm. Sci., 7, 182 (2017); https://doi.org/10.7324/JAPS.2017.70626
  41. J.K. Akintunde and A.K. Babaita, Middle East Fertil. Soc. J., 22, 211 (2017); https://doi.org/10.1016/j.mefs.2017.02.005
  42. N. Narra, S.S. Kaki, R.B.N. Prasad, S. Misra, K. Dhevendar, V. Kontham and P.V. Korlipara, Beilstein J. Org. Chem., 13, 26 (2017); https://doi.org/10.3762/bjoc.13.4
  43. S.M. Kawsar, M.O. Faruk, M.S. Rahman, Y. Fujii and Y. Ozeki, Sci. Pharm., 82, 1 (2014); https://doi.org/10.3797/scipharm.1308-03
  44. P.R. Ashton, E.F. Hounsell, N. Jayaraman, T.M. Nilsen, N. Spencer, J.F. Stoddart and M. Young, J. Org. Chem., 63, 3429 (1998); https://doi.org/10.1021/jo9804184
  45. H.H. Imad, J.H. Hussein, A.K. Muhanned and S.H. Nidaa, J. Pharmacog. Phytother., 7, 107 (2015); https://doi.org/10.5897/JPP2015.0349
  46. B.R. Kim, H.M. Kim, C.H. Jin, S.Y. Kang, J.B. Kim, Y.G. Jeon, K.Y.Park, I.S. Lee and A.R. Han, Plants, 9, 717 (2020); https://doi.org/10.3390/plants9060717
  47. N. Gurnani, M. Gupta, D. Mehta and B.K. Mehta, J. Taibah Univ. Sci., 10, 462 (2016); https://doi.org/10.1016/j.jtusci.2015.06.011
  48. F. Mazhar, R. Khanum, M. Ajaib and M. Jahangir, Pak. J. Pharm. Sci.,28, 2053 (2015).
Read More
Author biographies is not available.
Download
PDF
Statistic
Read Counter : 4 Download : 2