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Vol. 33 No. 3 (2021): Vol 33 Issue 3

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Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II)

https://doi.org/10.14233/ajchem.2021.23004
Narendra Kumar Singh
Department of Chemistry, Amrit Campus, Tribhuvan University, Kathmandu, Nepal
Smriti Shrestha
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India
Nerina Shahi
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India
Ravinder Kumar Choudhary
Department of Chemistry, Gurukula Kangri Vishwavidyalaya, Haridwar-249404, India
Anupa A. Kumbhar
Department of Chemistry, Savitribai Phule Pune University, Pune-411007, India
Yuba Raj Pokharel
Faculty of Life Science and Biotechnology, South Asian University, Akbar Bhawan, Chanakyapuri, New Delhi-110021, India
Paras Nath Yadav
Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal

Corresponding Author(s) : Yuba Raj Pokharel

yrp@sau.ac.in

Asian Journal of Chemistry, Vol. 33 No. 3 (2021): Vol 33 Issue 3

Abstract

5-Nitroisatin-4-(1-(2-pyridyl)piperazinyl)-3-thiosemicarbazone (Nitistpyrdlpz) and its Cu(II) complex were synthesized and characterized by CHN and thermal analysis and spectroscopic measurements viz. UV-vis, FTIR, 1H NMR, 13C NMR, ESI-HRMS, PXRD and EPR. In the complex, copper(II) ion is coordinated by terdentate thiosemicarbazone anion and one chloride ion in a distorted square planar geometry. The synthesized compounds against breast cancer cell lines; MCF-7 and MDA-MB-231 and epidermoid carcinoma; A431 showed that the complex contributed to reduce the percentage of cell viability toward all the tested cell lines but remarkable contribution toward MDA-MB-231 cell line. The IC50 of the complex and free ligand was found in the range of IC50 0.85-1.24 μM and IC50 3.28-3.53 μM, respectively. Among those cell lines, the complex may be the better anticancer agent toward MDA-MB-231 because of its action at micromolar concentration (IC50 0.85 μM).

Keywords

Anticancer activity Copper(II) complex MDA-MB-231 cell line 5-Nitroisatin Thiosemicarbazone
Kumar Singh, N., Shrestha, S., Shahi, N., Kumar Choudhary, R., A. Kumbhar, A., Raj Pokharel, Y., & Nath Yadav, P. (2021). Enhancement of Anticancer Activity of N(4)1-(2-Pyridyl)piperazinyl 5-Nitroisatin Thiosemicarbazone on Chelation with Copper(II). Asian Journal of Chemistry, 33(3), 557–564. https://doi.org/10.14233/ajchem.2021.23004
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