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Vol. 30 No. 7 (2018): Vol 30 Issue 7

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Green Synthesis, Characterization and Antidiabetic Activity of 2-Substituted Aryl/Alkyl-N-Aryl/Alkyl Imidazo[1,2-a]pyridin-3-amine Derivatives

https://doi.org/10.14233/ajchem.2018.21220
Tata Veereswara Rao Kota
Department of Chemistry, Bonam Venkata Chalamayya Engineering College, Odalarevu, Allavaram Mandal-533 201, India; Department of Chemistry, Jawaharlal Nehru Technological University Kakinada, Kakinada-533 003, India
Hima Bindu Gandham
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530 003, India
Paul Douglas Sanasi
Department of Engineering Chemistry, AU College of Engineering (A), Andhra University, Visakhapatnam-530 003, India

Corresponding Author(s) : Tata Veereswara Rao Kota

veresh.kota@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 7 (2018): Vol 30 Issue 7

Abstract

Imidazo[1,2-a]pyridines containing ring junction have shown broad therapeutic properties in the drug discovery sector, such as the treatment of heart disease, migraines, digestive disease and viral disease. Imidazo[1,2-a]pyridine structure is very much prevalent in several marketed drugs viz., olprinone, zolpidem, levamisole, alpidem, zolimidine etc. The present paper describes the green synthesis of some novel imidazo[1,2-a]pyridine derivatives (6a-f/7a-f), a straight forward, isocyanide based Groebke-Blackburn-Bienayme, three component reactions in which aldehyde, 2-aminopyridine and isocyanide are condensed in presence of green parameters such as (i) ZnO nanoparticles/ZnFe2O4 nanoparticles (reusable heterogeneous catalysts), (ii) 2-methyl-tetrahydrofuran (green solvent) and (iii) microwave irradiation (energy efficiency reducing time period of the reaction). These derivatives were evaluated for antidiabetic experiments and the results revealed that most of the compounds were active towards antidiabetic property.

Keywords

Green synthesis Imidazo[1,2-a]pyridine Antidiabetic 2-Amino-pyridine ZnO nanoparticles ZnFe2O4 nanoparticles
Rao Kota, T. V., Gandham, H. B., & Sanasi, P. D. (2018). Green Synthesis, Characterization and Antidiabetic Activity of 2-Substituted Aryl/Alkyl-N-Aryl/Alkyl Imidazo[1,2-a]pyridin-3-amine Derivatives. Asian Journal of Chemistry, 30(7), 1531–1536. https://doi.org/10.14233/ajchem.2018.21220
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