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Vol. 30 No. 7 (2018): Vol 30 Issue 7

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Synthesis, Single Crystal XRD and Molecular Docking of 3-α-Carboxy Ethyl Rhodanine

https://doi.org/10.14233/ajchem.2018.21161
Kaveri Sundaram
Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore-641 021, India
Subban Ravi
Department of Chemistry, Karpagam Academy of Higher Education, Coimbatore-641 021, India
Muthurajan Thenmozhi
Centre for Nanotechnology and Advanced Biomaterials (CeNTAB), School of Chemical and Biotechnology, SASTRA University, Thanjavur-613 401, India
Veeran Mohanraj
Postgraduate & Research Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore-641 020, India

Corresponding Author(s) : Subban Ravi

ravisubban@rediffmail.com

Asian Journal of Chemistry, Vol. 30 No. 7 (2018): Vol 30 Issue 7

Abstract

The crystal product of 3-α-carboxy ethyl rhodanine was confirmed by single crystal XRD analysis. Furthermore, to examine the binding interactions of 3-α-carboxy ethyl rhodanine with the Bcr AblT315I tyrosine kinase and HPV 16 E2 protein molecular docking study was carried out. The results showed reasonable docking scores and displayed good interactions, thereby suggesting that 3-α-carboxy ethyl rhodanine may be used as a template for the further development of anticancer drugs.

Keywords

3-α-Carboxy ethyl rhodanine SXRD Bcr AblT315I tyrosine kinase HPV 16 E2 protein Molecular docking
Sundaram, K., Ravi, S., Thenmozhi, M., & Mohanraj, V. (2018). Synthesis, Single Crystal XRD and Molecular Docking of 3-α-Carboxy Ethyl Rhodanine. Asian Journal of Chemistry, 30(7), 1446–1450. https://doi.org/10.14233/ajchem.2018.21161
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References
  1. B.C.C. Cantello, M.A. Cawthorne, D. Haigh, R.M. Hindley, S.A. Smith and P.L. Thurlby, Bioorg. Med. Chem. Lett., 4, 1181 (1994); https://doi.org/10.1016/S0960-894X(01)80325-5.
  2. P. Villain-Guillot, M. Gualtieri, L. Bastide, F. Roquet, J. Martinez, M. Amblard, M. Pugniere and J.P. Leonetti, J. Med. Chem., 50, 4195 (2007); https://doi.org/10.1021/jm0703183.
  3. S. Yan, G. Larson, J.Z. Wu, T. Appleby, Y. Ding, R. Hamatake, Z. Hong and N. Yao, Bioorg. Med. Chem. Lett., 17, 63 (2007); https://doi.org/10.1016/j.bmcl.2006.09.095.
  4. R.F. Kletzien, S.D. Clarke and R.G. Ulrich, Mol. Pharmacol., 41, 393 (1992).
  5. E.S. Raper, Coord. Chem. Rev., 61, 115 (1985); https://doi.org/10.1016/0010-8545(85)80004-7.
  6. M.G. Orchard, J.C. Neuss, C.M.S. Galley, A. Carr, D.W. Porter, P. Smith, D.I.C. Scopes, D. Haydon, K. Vousden, C.R. Stubberfield, K. Young and M. Page, Bioorg. Med. Chem. Lett., 14, 3975 (2004); https://doi.org/10.1016/j.bmcl.2004.05.050.
  7. M.W. Irvine, G.L. Patrick, J. Kewney, S.F. Hastings and S.J. MacKenzie, Bioorg. Med. Chem. Lett., 18, 2032 (2008); https://doi.org/10.1016/j.bmcl.2008.01.117.
  8. S.L. Johnson, L.H. Chen, R. Harbach, M. Sabet, A. Savinov, N.J.H. Cotton, A. Strongin, D. Guiney and M. Pellecchia, Chem. Biol. Drug Des., 71, 131 (2008); https://doi.org/10.1111/j.1747-0285.2007.00617.x.
  9. N.S. Cutshall, C. O’Day and M. Prezhdo, Bioorg. Med. Chem. Lett., 15, 3374 (2005); https://doi.org/10.1016/j.bmcl.2005.05.034.
  10. M.M. Sim, S.B. Ng, A.D. Buss, S.C. Crasta, K.L. Goh and S.K. Lee, Bioorg. Med. Chem. Lett., 12, 697 (2002); https://doi.org/10.1016/S0960-894X(01)00832-0.
  11. G. Kumar, P. Parasuraman, S.K. Sharma, T. Banerjee, K. Karmodiya, N. Surolia and A. Surolia, J. Med. Chem., 50, 2665 (2007); https://doi.org/10.1021/jm061257w.
  12. R. Dayam, T. Sanchez, O. Clement, R. Shoemaker, S. Sei and N. Neamati, J. Med. Chem., 48, 111 (2005); https://doi.org/10.1021/jm0496077.
  13. A.R. Katritzky, S.R. Tala, H. Lu, A.V. Vakulenko, J. Sivapackiam, Q.Y. Chen, K. Pandya, S. Jiang and A.K. Debnath, J. Med. Chem., 52, 7631 (2009); https://doi.org/10.1021/jm900450n.
  14. G. Maga, F. Falchi, A. Garbelli, A. Belfiore, M. Witvrouw, F. Manetti and M. Botta, J. Med. Chem., 51, 6635 (2008); https://doi.org/10.1021/jm8008844.
  15. S. Rajamaki, A. Innitzer, C. Falciani, C. Tintori, F. Christ, M. Witvrouw, Z. Debyser, S. Massa and M. Botta, Bioorg. Med. Chem. Lett., 19, 3615 (2009); https://doi.org/10.1016/j.bmcl.2009.04.132.
  16. E.B. Grant, D. Guiadeen, E.Z. Baum, B.D. Foleno, D.A. Montenegro, H. Jin, E.A. Nelson, K. Bush and D. Hlasta, Bioorg. Med. Chem. Lett., 10, 2179 (2000); https://doi.org/10.1016/S0960-894X(00)00444-3.
  17. P.F. Kador, J.H. Kinoshita and N.E. Sharpless, J. Med. Chem., 28, 841 (1985); https://doi.org/10.1021/jm00145a001.
  18. R. Kikkawa, I. Hatanaka, H. Yasuda, N. Kobayashi, H. Terashima, Y. Shigeta, T. Morimura and M. Tsuboshima, Diabetologia, 24, 290 (1983); https://doi.org/10.1007/BF00282716.
  19. K. Sundaram and S. Ravi, Asian J. Chem., 25, 10353 (2013); https://doi.org/10.14233/ajchem.2013.15467.
  20. A. Bondi, J. Phys. Chem., 68, 441 (1964); https://doi.org/10.1021/j100785a001.
  21. R.S. Rowland and R. Taylor, J. Phys. Chem., 100, 7384 (1996); https://doi.org/10.1021/jp953141+.
  22. M.E. Sherman, S.S. Wang, J. Carreon and S.S. Devesa, Cancer, 103, 1258 (2005); https://doi.org/10.1002/cncr.20877.
  23. W.C. Phelps and P.M. Howley, J. Virol., 61, 1630 (1987).
  24. B.A. Van Tine, L.D. Dao, S.Y. Wu, T.M. Sonbuchner, B.Y. Lin, N. Zou, C.M. Chiang, T.R. Broker and L.T. Chow, Proc. Natl. Acad. Sci. USA, 101, 4030 (2004); https://doi.org/10.1073/pnas.0306848101.
  25. A.A. Antson, J.E. Burns, O.V. Moroz, D.J. Scott, C.M. Sanders, I.B. Bronstein, G.G. Dodson, K.S. Wilson and N.J. Maitland, Mol. Cell. Biol., 17, 7208 (1997); https://doi.org/10.1128/MCB.17.12.7208.
  26. D.E. Breiding, F. Sverdrup, M.J. Grossel, N. Moscufo, W. Boonchai, and E.J. Androphy, Mol. Cell. Biol., 17, 7208 (1997); https://doi.org/10.1128/MCB.17.12.7208.
  27. C.S. Cooper, S.N. Upmeyer and P.L. Winokur, Virology, 241, 312 (1998); https://doi.org/10.1006/viro.1997.8941.
  28. R.S. Hegde and E.J. Androphy, J. Mol. Biol., 284, 1479 (1998); https://doi.org/10.1006/jmbi.1998.2260.
  29. J.M. Yao, D.E. Breiding and E.J. Androphy, J. Virol., 72, 1013 (1998).
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