Synthesis and Characterization of New Derivative of Norfloxacin Containing an N Substituted Piperazine Moiety
Corresponding Author(s) : KARIM MASOOD TAGHI-GANJI
km.tgangi@yahoo.com
Asian Journal of Chemistry,
Vol. 21 No. 5 (2009): Vol 21 Issue 5
Abstract
N-(Aryl) norfloxacin derivative that bear a hydroxyimino-substituent has been synthesized. Here, intermediate compound 2 was synthesized from benzylidineacetone in presence of bromine in acetic acid. Then this compound was reacted with hydroxyamine to give compound 3. The reaction of this compound with norfloxacin in the presence of NaHCO3 gave norfloxacin analog 4. The products were confirmed by IR, mass or 1H NMR spectra.
Keywords
Piperazinyl quinolones
Norfloxacin derivative
Synthesis
MASOOD TAGHI-GANJI, K. (2010). Synthesis and Characterization of New Derivative of Norfloxacin Containing an N Substituted Piperazine Moiety. Asian Journal of Chemistry, 21(5), 3851–3854. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/17406
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