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Vol. 30 No. 6 (2018): Vol 30 Issue 6

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Synthesis and Characterization of Novel Diorganotin(IV) Complexes Derived from N-Methyl-phenethyl Dithiocarbamate and Bis(2-ethoxyethyl) Dithiocarbamate

https://doi.org/10.14233/ajchem.2018.21253
Norraphat Uttraphan Pim
Biomedical Science Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Normah Awang
Environmental Health and Industrial Safety Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Rapidah Mohamad
Biomedical Science Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia
Yang Farina Abdul Aziz
School of Chemical Sciences and Food Technology, Faculty of Science & Technology, Universiti Kebangsaan Malaysia, 43600 Bangi, Selangor Darul Ehsan, Malaysia
Nurul Farahana Kamaludin
Environmental Health and Industrial Safety Programme, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia

Corresponding Author(s) : Nurul Farahana Kamaludin

nurulfarahana@ukm.edu.my

Asian Journal of Chemistry, Vol. 30 No. 6 (2018): Vol 30 Issue 6

Abstract

Organotin(IV) dithiocarbamate complexes are extensively studied worldwide as they have proven to exhibit promising anticancer, antimicrobial and larvicidal properties. In this study, three new organotin(IV) dithiocarbamate complexes have been successfully synthesized via in situ reaction between the appropriate secondary amines with carbon disulphide and organotin(IV) salts, in a basic solution at temperature below 4 °C. The complexes were characterized by CHNS elemental analysis, FTIR and 1H, 13C and 119Sn NMR. All complexes displayed the important NCS2 peak from 200.02-201.35 ppm in 13C NMR, signifying the presence of the dithiocarbamate ligand. The complexes also produced the essential IR bands, ν(C-N), ν(C-S) and ν(Sn-C) in the ranges 1489 to 1479 cm–1, 986.2 to 971.2 cm–1 and 568.2 to 550.8 cm–1, respectively. From the 119Sn NMR, both the ligands were suggested to coordinate to the tin atom in a bidentate manner in all three complexes.

Keywords

Organotin(IV) Dithiocarbamate Anticancer Nanoparticles
Pim, N. U., Awang, N., Mohamad, R., Abdul Aziz, Y. F., & Kamaludin, N. F. (2018). Synthesis and Characterization of Novel Diorganotin(IV) Complexes Derived from N-Methyl-phenethyl Dithiocarbamate and Bis(2-ethoxyethyl) Dithiocarbamate. Asian Journal of Chemistry, 30(6), 1364–1368. https://doi.org/10.14233/ajchem.2018.21253
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