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Vol. 30 No. 5 (2018): Vol 30 Issue 5, 2018

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Preparation, Characterization and Biological Activity of New Tridentate Imine-Oxime Ligand (H2L) and Its Metal Complexes

https://doi.org/10.14233/ajchem.2018.21257%20
Basim H. Al-Zaidi
Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
Ahmed H. Ismail
Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq
Ali N. Naseaf
Department of Chemistry, College of Education Ibn al-Haytham, University of Bahgdad, Baghdad, Iraq
Wessal Khamis
Department of Chemistry, College of Science, Al-Mustansiriyah University, Baghdad, Iraq

Corresponding Author(s) : Basim H. Al-Zaidi

basimhatim@uomustansiriyah.edu.iq

Asian Journal of Chemistry, Vol. 30 No. 5 (2018): Vol 30 Issue 5, 2018

Abstract

The new tridentate Schiff-oxime ligand 1-[2-(2,4-dihydroxybenzylidene)aminophenyl]ethanone oxime (H2L), prepared via condensation of equal amounts of 1-(2-aminophenyl)ethanone oxime and 4-hydroxysalicylaldehyde. H2L ligand characterized by using FTIR, UV-visible spectroscopies, 1H NMR, 13C NMR spectra and Mass spectrum. Metal ions complexes with Cr3+, Mn2+, Co2+, Ni2+ and Cu2+ ions, prepared in a M:L (1:2) ratio and characterized by IR, UV-visible spectroscopies, magnetic susceptibility, molar conductivity and flame atomic absorption measurements. Results of spectral studies proved the chelation behaviour of this ligand, which coordinated to metal ions as a monobasic NNO tridentate ligand, via imine and oxime nitrogen atoms in addition to phenolic oxygen atom, after losing its proton. The proposed geometry of all the prepared complexes was octahedral. The minimal inhibition zone against two Gram-positive (Staphylococcus aureus and Staphylococcus epidermidis) and two Gram-negative bacteria (E. coli and Klebsella spp.) also determined.

Keywords

NNO tridentate Schiff-oxime Metal complexes o-Aminoacetophenone oxime 4-Hydroxy-salicylaldehyde Antibacterial activity
Al-Zaidi, B. H., Ismail, A. H., Naseaf, A. N., & Khamis, W. (2018). Preparation, Characterization and Biological Activity of New Tridentate Imine-Oxime Ligand (H2L) and Its Metal Complexes. Asian Journal of Chemistry, 30(5), 1157–1164. https://doi.org/10.14233/ajchem.2018.21257
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