Synthesis and Characterization of Complexes of Some Bivalent Metal Ions with Omeprazole

Abstract

The Hg(II) and Mn(II) complexes have been synthesized with 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl sulfinyl]- ¹H-benzimidazole (omeprazole). Omeprazole is a proton pump inhibitor (PPI). Analytical data and stochiometry suggest ligand metal ratio of 2:1 for both Hg(II) and Mn(II) complexes. The ligand behaves as a bidentate N, O donors. The complexes have been synthesized and characterized by elemental analysis, magnetic susceptibility and infrared spectrum studies. The complexes have been formulated as (C₁₇H₁₉N₃O₃S)₂Hg and (C₁₇H₁₉N₃O₃S)₂Mn·2H₂O.