Isolation, Identification and Characterization of Process Related Impurities in Losartan Potassium Drug Substance
Corresponding Author(s) : M. THAPA
manish.thapa@alembic.co.in
Asian Journal of Chemistry,
Vol. 22 No. 6 (2010): Vol 22 Issue 6
Abstract
Two impurities in losartan drug substance at level ca. 0.5 % is detected by RP-HPLC. These impurities are isolated from the impurity enriched sample using reversed phase preparative HPLC. Based on the spectral data (IR, NMR and MS) both the impurities are characterized as Positional Dimer of Losartan having same molecular weight.
Keywords
Impurity
Spectroscopy
Isolation
Identification
Characterization
Separation
THAPA, M., NAUTIYAL, R., DATAR, M., & SINGH, A. (2010). Isolation, Identification and Characterization of Process Related Impurities in Losartan Potassium Drug Substance. Asian Journal of Chemistry, 22(6), 4295–4298. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16803
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX