A Factorial Study to Evaluate the Individual and Combined Effects of β-Cyclodextrin and Tween 80 on the Solubility and Dissolution Rate of Aceclofenac

Abstract

The individual and combined effects of b-cyclodextrin and Tween 80 (surfactant) on the solubility and dissolution rate of aceclofenac were evaluated in a 22-factorial study. The solubility of aceclofenac in the four selected fluids containing b-cyclodextrin and Tween 80, as per 22- factorial study, was determined. The solubility of aceclofenac was markedly enhanced by b-cyclodextrin (1.57 fold), Tween 80 (7.91 fold) individually as well as combinedly (10.5 fold). Both the individual and combined effects were significant (p < 0.05). Aceclofenac-b-cyclodextrin complexes with and without Tween 80 were prepared by kneading method and were evaluated for dissolution rate and dissolution efficiency (DE15) as per a 22-factorial design. b-Cyclodextrin alone gave marked enhancement in the dissolution rate and DE15 of aceclofenac. The main effect of b-cyclodextrin and the combined effect of b-cyclodextrin and Tween 80 in enhancing the dissolution rate were significant (p < 0.05). Though Tween 80 has increased the solubility of aceclofenac, it has not significantly enhanced the dissolution rate of aceclofenac.