Synthesis of Bromo Substituted-4-biphenyl Acetamide Derivatives

Abstract

A number of bromo substituted-4-biphenyl-amides have been synthesized by condensation of 4-biphenyl acetic acid with bromine in acetic acid (in ice-cool media). Bromo substituted-4BPAA is then treated with SOCl₂ in dry benzene to prepare bromo substituted-4-biphenyl acetyl chloride, which is then treated with different aliphatic or aromatic amines to synthesized various bromo substituted-4-biphenyl acetamides. The structure of newly synthesized compounds have been established by analytical and spectral methods.