Effect of Magnetic Field on Plasma Zn, Cu and Malondialdehyde Levels and Na+-K+ Atpase Activity of Isolated Diaphragmatic Muscle in a Diabetic Rat Model

Abstract

The aim of this study is to investigate the effect of magnetic field

(MF) on plasma Zn, Cu and malondialdehyde (MDA) levels and Na⁺-K⁺

ATPase activity of isolated diaphragmatic muscle in a diabetic rat model.

Rats allocated as control (n = 10), diabetes mellitus (DM) (n = 10), MFexposed

(MFE) (n = 10) and DM plus MF-exposed (DM-MFE) (n = 10)

groups. After induced DM, the MF were exposed to MF in solenoid

165 minutes every day during 1 month. Cardiac blood was obtained

and the plasma Zn, Cu and MDA levels and Na⁺- K⁺ ATPase activity of

diaphragmatic muscle were determined. Plasma Cu level of the control

was significantly lower than those of the DM and MFE (p < 0.05).

Plasma Zn level of the DM-MFE was significantly lower than those of

the control, DM and MFE (p < 0.05). Plasma MDA level of the DM

was significantly higher than those of the control, MFE and DM-MFE

(p < 0.05). Diabetes mellitus and magnetic field increase plasma Cu level

and do not affect plasma Zn level, but MF plus DM decreases its level.

While DM increases plasma MDA level, MF has opposing effect on

MDA level. Diabetes mellitus decreases Na-K ATPase of rat diaphragmatic

muscle and MF elevates its level to normal.