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Some Cyclization Reactions of 6-Mercaptopurine with Expected Biological Activity
Asian Journal of Chemistry,
Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010
Abstract
The reaction of 6-mercaptopurine 1 with aromatic ketones 2a-h using
the acidified acetic acid method afforded the S-acetyl derivatives 3a-h
in good yields. While, the cyclized product 4i was obtained directly
upon reaction of 1 with 9-acetyl anthracene. Compounds 3a-h were
cyclized directly to the corresponding 1,4-thiazino[2,3,4-bc]purine
derivatives (4a-h). In the same manner the reaction of 1 with aliphatic,
aromatic, alicyclic ketones, α-tetralone and 1-methyl-4-piperidone gave
compounds 6, 7, 8, 9a,b, 11 and 12. The cyclized compounds 10a,b
were obtained by cyclization of 9a,b. The synthesized compounds were
screened for their in vitro antitumor activity at National Cancer Institute.
the acidified acetic acid method afforded the S-acetyl derivatives 3a-h
in good yields. While, the cyclized product 4i was obtained directly
upon reaction of 1 with 9-acetyl anthracene. Compounds 3a-h were
cyclized directly to the corresponding 1,4-thiazino[2,3,4-bc]purine
derivatives (4a-h). In the same manner the reaction of 1 with aliphatic,
aromatic, alicyclic ketones, α-tetralone and 1-methyl-4-piperidone gave
compounds 6, 7, 8, 9a,b, 11 and 12. The cyclized compounds 10a,b
were obtained by cyclization of 9a,b. The synthesized compounds were
screened for their in vitro antitumor activity at National Cancer Institute.
Keywords
Cyclization reactions
6-Mercaptopurine
Biological activity.
HASSAN, A. (2024). Some Cyclization Reactions of 6-Mercaptopurine with Expected Biological Activity. Asian Journal of Chemistry, 22(1), 689–698. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16695
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