Synthesis of 2[N-Cinnamlideneamino]-5-Nitro Phenol and Its Metal(II) Complexes and Evaluation of Their Antitumor Activities

Abstract

The preparation of a series of metal(II) complexes (Zn, Cu, Co and

Ni) with 2[N-(cinnamlidene)amino]-5-nitro phenol as a novel ligand

and their biological evaluation against six species of pathogenic yeasts

(Candida albicans, C. fructus, C. glabrata, C. oleophila, C. parapsilosis

and C. tropicalis) are described. All new compounds were fully characterized

by elemental analyses, spectroscopic measurements (IR, UV-vis,

NMR, ESR and EIMS) as well as thermal and magnetic susceptibility

measurements. Studies revealed that HL ligand acts as bidentate through

N and O atoms. Zn(II) and Co(II) complexes exhibited tetrahedral

geometry while Cu(II), Ni(II) are octahedral. Both Co(II) and Zn(II)

complexes exhibited potential antitumor activities and the latter showed

promising cytotoxicity (70-82 % cell mortality) and it may be considered

a new antitumor agents.