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Synthesis of 2[N-Cinnamlideneamino]-5-Nitro Phenol and Its Metal(II) Complexes and Evaluation of Their Antitumor Activities
Asian Journal of Chemistry,
Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010
Abstract
The preparation of a series of metal(II) complexes (Zn, Cu, Co and
Ni) with 2[N-(cinnamlidene)amino]-5-nitro phenol as a novel ligand
and their biological evaluation against six species of pathogenic yeasts
(Candida albicans, C. fructus, C. glabrata, C. oleophila, C. parapsilosis
and C. tropicalis) are described. All new compounds were fully characterized
by elemental analyses, spectroscopic measurements (IR, UV-vis,
NMR, ESR and EIMS) as well as thermal and magnetic susceptibility
measurements. Studies revealed that HL ligand acts as bidentate through
N and O atoms. Zn(II) and Co(II) complexes exhibited tetrahedral
geometry while Cu(II), Ni(II) are octahedral. Both Co(II) and Zn(II)
complexes exhibited potential antitumor activities and the latter showed
promising cytotoxicity (70-82 % cell mortality) and it may be considered
a new antitumor agents.
Ni) with 2[N-(cinnamlidene)amino]-5-nitro phenol as a novel ligand
and their biological evaluation against six species of pathogenic yeasts
(Candida albicans, C. fructus, C. glabrata, C. oleophila, C. parapsilosis
and C. tropicalis) are described. All new compounds were fully characterized
by elemental analyses, spectroscopic measurements (IR, UV-vis,
NMR, ESR and EIMS) as well as thermal and magnetic susceptibility
measurements. Studies revealed that HL ligand acts as bidentate through
N and O atoms. Zn(II) and Co(II) complexes exhibited tetrahedral
geometry while Cu(II), Ni(II) are octahedral. Both Co(II) and Zn(II)
complexes exhibited potential antitumor activities and the latter showed
promising cytotoxicity (70-82 % cell mortality) and it may be considered
a new antitumor agents.
Keywords
Schiff base
Complexes
Antitumor
Cytotoxicity.
FAWZY EL-HUSSEINY, A. (2009). Synthesis of 2[N-Cinnamlideneamino]-5-Nitro Phenol and Its Metal(II) Complexes and Evaluation of Their Antitumor Activities. Asian Journal of Chemistry, 22(1), 603–614. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16684
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