Spectrophotometric Methods for Simultaneous Estimation of Diclofenac Sodium and Rabeprazole in Combined Dosage Form

Abstract

Two fast, precise and economical spectrophotometric methods have

been developed for the simultaneous estimation of diclofenac sodium

and rabeprazole in a combined dosage form. Simultaneous determination

of the marketed brands was carried out using simultaneous equation

method and two wavelength calculation methods. An attempt was made

to estimate both the drugs in a combined dosage form. Methanol was

used as a common solvent for both the drugs. Linearity was observed at

both wavelengths in the concentration range of 10-50 μg/mL for each

drug. The result of analysis have been validated statistically and also by

recovery studies.