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Promotional Effect of Tertiary Amine on Asymmetric Catalytic Hydrogenation of Ethyl Pyruvate Over Pt/Al2O3 in Acetic Acid
Asian Journal of Chemistry,
Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010
Abstract
In the asymmetric hydrogenation of ethyl pyruvate over cinchona
alkaloid modified Pt/Al2O3 in acetic acid under atmospheric pressure,
the enantioselectivity was improved and the reaction rate was accelerated
upon addition of tertiary amine. The size of the alkyl substitute in tertiary
amine molecule has significant impact on the improvement. Triethylamine
is the most effective additive compared with tri-n-butylamine,
tri-n-propylamine and trimethylamine. There is an optimum adding
amount (0.4 mol/L) of all tertiary amines, at which triethylamine can
increase the enantioselectivity of product from 51 to 72 %. The role of
tertiary amine in the promotional effect was discussed.
alkaloid modified Pt/Al2O3 in acetic acid under atmospheric pressure,
the enantioselectivity was improved and the reaction rate was accelerated
upon addition of tertiary amine. The size of the alkyl substitute in tertiary
amine molecule has significant impact on the improvement. Triethylamine
is the most effective additive compared with tri-n-butylamine,
tri-n-propylamine and trimethylamine. There is an optimum adding
amount (0.4 mol/L) of all tertiary amines, at which triethylamine can
increase the enantioselectivity of product from 51 to 72 %. The role of
tertiary amine in the promotional effect was discussed.
Keywords
Asymmetric hydrogenation
Promotional effect
Tertiary amine
Ethyl pyruvate
Cinchona alkaloid
Pt/Al2O3.
TAO, G., LU*, G., GUO, Y., WANG, Y., & GUO, Y. (2009). Promotional Effect of Tertiary Amine on Asymmetric Catalytic Hydrogenation of Ethyl Pyruvate Over Pt/Al2O3 in Acetic Acid. Asian Journal of Chemistry, 22(1), 461–467. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16665
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