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Leptin and Nutritional Markers in Childhood Protein-Energy Malnutrition
Asian Journal of Chemistry,
Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010
Abstract
Leptin is an important signal in metabolic/endocrine adaptation to
prolonged nutritional deprivation. This cross-sectional study was performed
to determine alterations associated with protein-energy malnutrition
in serum levels of leptin and classical nutritional markers. Forty-two
children with protein-energy malnutrition was classified according to
Gomez and 21 healthy controls were recruited. Serum leptin, albumin,
prealbumin, fibronectin, transferrin, lipoprotein (a) and whole blood
hemoglobin concentrations were determined. Leptin levels were significantly
lower in undernourished children, declining with degree of
malnutrition. Alteration of albumin, hemoglobin and lipoprotein (a)
became apparent at late stages of malnutrition. Gomez classification
was the only significant contributor to the variations in leptin concentrations
among age, weight, presence of infection, breast-feeding duration
and age at feeding with complementary foods. This study provides evidence
that leptin is sensitive to stages of malnutrition independent of body
weight, probably for it's role in metabolic adaptation. Serum prealbumin,
transferrin and fibronectin does not offer a sensitive alternative in the
background of increased susceptibility to infection.
prolonged nutritional deprivation. This cross-sectional study was performed
to determine alterations associated with protein-energy malnutrition
in serum levels of leptin and classical nutritional markers. Forty-two
children with protein-energy malnutrition was classified according to
Gomez and 21 healthy controls were recruited. Serum leptin, albumin,
prealbumin, fibronectin, transferrin, lipoprotein (a) and whole blood
hemoglobin concentrations were determined. Leptin levels were significantly
lower in undernourished children, declining with degree of
malnutrition. Alteration of albumin, hemoglobin and lipoprotein (a)
became apparent at late stages of malnutrition. Gomez classification
was the only significant contributor to the variations in leptin concentrations
among age, weight, presence of infection, breast-feeding duration
and age at feeding with complementary foods. This study provides evidence
that leptin is sensitive to stages of malnutrition independent of body
weight, probably for it's role in metabolic adaptation. Serum prealbumin,
transferrin and fibronectin does not offer a sensitive alternative in the
background of increased susceptibility to infection.
Keywords
Protein-energy malnutrition
Leptin
Lipoprotein (a)
Prealbumin
Fibronectin
Transferrin.
ERBAGCI*, A., KILINdž, M., TARAKÇIOGLU, M., TAYSI, S., & KOCABAS, R. (2009). Leptin and Nutritional Markers in Childhood Protein-Energy Malnutrition. Asian Journal of Chemistry, 22(1), 373–378. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16657
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