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Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010

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Application of Oxidative Coupling Reactions for Estimation of Lercanidipine Hydrochloride in Formulations

T. MANIKYA SASTRY*
Department of Chemistry, G.V.P. College of Engineering, Visakhapatnam-530 048, India E-mail: tmsastry@yahoo.com Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam-530 045, India; E-mail: karipeddi_rk@yahoo.com
K. RAMAKRISHNA†
Department of Chemistry, G.V.P. College of Engineering, Visakhapatnam-530 048, India E-mail: tmsastry@yahoo.com Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam-530 045, India; E-mail: karipeddi_rk@yahoo.com

Asian Journal of Chemistry, Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010

Abstract

Two simple and sensitive visible spectrophotometic methods (A and B) have been developed for the assay of lercanidipine hydrochloride in bulk and formulations. Methods A and B are based on the formation of colour species by means of forming oxidative coupling reactions with 4-aminophenazone/IO4 (λmax = 520) and N,N′-dimethylamino-p-phenyl-enediamine/chloramine- T (λmax = 550). The results of analysis have been validated statistically and recovery studies range from 99.4 to 100.5 % for the routine assay of lercanidipine hydrochloride formulations.

Keywords

u Spectrophotometry Lercanidipine hydrochloride 4-Aminophenazone N N-Dimethylamino-p-phenylenediamine Chloramine-T.
MANIKYA SASTRY*, T., & RAMAKRISHNA†, K. (2024). Application of Oxidative Coupling Reactions for Estimation of Lercanidipine Hydrochloride in Formulations. Asian Journal of Chemistry, 22(1), 253–259. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16641
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