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Application of Oxidative Coupling Reactions for Estimation of Lercanidipine Hydrochloride in Formulations
Asian Journal of Chemistry,
Vol. 22 No. 1 (2010): Vol 22 Issue 1, 2010
Abstract
Two simple and sensitive visible spectrophotometic methods (A and B) have been developed for the assay of lercanidipine hydrochloride in bulk and formulations. Methods A and B are based on the formation of colour species by means of forming oxidative coupling reactions with 4-aminophenazone/IO4 (λmax = 520) and N,N′-dimethylamino-p-phenyl-enediamine/chloramine- T (λmax = 550). The results of analysis have been validated statistically and recovery studies range from 99.4 to 100.5 % for the routine assay of lercanidipine hydrochloride formulations.
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