Organosilicon(IV) Complexes of 3-Hydroxy-2-pyridine Carboxylic Acid and 2-Pyridine Carboxylic Acid and Their Antimicrobial Activity

Abstract

Organosilicon(IV) complexes of the types R₂Si(Cl)_n(L₁-L₂)_2-n where (R = methyl, ethyl or phenyl, L₁ = 3-hydroxy-2-pyridinecarboxylate and L₂ = 2-pyridine carboxylate, n = 0 or 1) have been synthesized and characterized by elemental analyses, IR, ¹H, ¹³C and ²⁹Si NMR spectroscopy. These studies indicated that ligands L₁ and L₂ chelated through nitrogen of pyridine and oxygen of carboxylate group and have penta- and hexa-coordinated state around the silicon atom. The ligands and their organosilicon complexes have been screened for their in vitro antimicrobial activities against several fungi and bacteria in order to explore their possibility to use as biocidal agents.