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An Efficient, Solvent Free Synthesis of Some Chalcone Derivatives and Their Biological Evaluation
Corresponding Author(s) : M. Fathimunnisa
Asian Journal of Chemistry,
Vol. 30 No. 4 (2018): Vol 30 Issue 4
Abstract
A solvent free grinding approach was adopted for the synthesis of (E)-1-(2',4'-difluorobiphenyl-4-yl)-3-arylprop-2-en-1-one derivatives. The synthesized derivatives were characterized by elemental analysis, mass, IR and NMR spectrometry. The in vitro antimicrobial activity of the derivatives showed moderate to potent activities against the tested microbes. Molecular docking studies were performed to evaluate the anticancer activities.
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- C.J. Li, Chem. Rev., 105, 3095 (2005); https://doi.org/10.1021/cr030009u.
- M. Sathishkumar, P. Shanmugavelan, S. Nagarajan, M. Dinesh and A. Ponnuswamy, New J. Chem., 37, 488 (2013); https://doi.org/10.1039/C2NJ40733G.
- S. Zangade, S. Mokle, A. Vibhute and Y. Vibhute, Chem. Sci. J., 2, 1 (2011).
- R. Gupta, A.K. Gupta, S. Paul and P.L. Kachroo, Indian J. Chem., 34B, 61 (1995).
- J.T. Li, W.Z. Yang, S.X. Wang, S.H. Li and T.S. Li, Ultrason. Sonochem., 9, 237 (2002); https://doi.org/10.1016/S1350-4177(02)00079-2.
- A.T. Dinkova-Kostova, C. Abeygunawardana and P. Talalay, J. Med. Chem., 41, 5287 (1998); https://doi.org/10.1021/jm980424s.
- V.J. Ram, A.S. Saxena, S. Srivastava and S. Chandra, Med. Chem. Lett., 10, 2159 (2000); https://doi.org/10.1016/S0960-894X(00)00409-1.
- M. Kidwai, P. Sapra, P. Misra, R.K. Saxena and M. Singh, Bioorg. Med. Chem., 9, 217 (2001); https://doi.org/10.1016/S0968-0896(00)00245-5.
- J.F. Ballesteros, M.J. Sanz, A. Ubeda, M.A. Miranda, S. Iborra, M. Paya and M.J. Alcaraz, J. Med. Chem., 38, 2794 (1995); https://doi.org/10.1021/jm00014a032.
- S.H. Lee, J.X. Nan, Y.Z. Zhao, S.W. Woo, E.J. Park, T.H. Kang, G.S. Seo, Y.C. Kim and D.H. Sohn, Planta Med., 69, 990 (2003); https://doi.org/10.1055/s-2003-45143.
- M. Fathimunnisa, H. Manikandan and S. Selvanayagam, J. Mol. Struct., 1099, 407 (2015); https://doi.org/10.1016/j.molstruc.2015.06.078.
References
C.J. Li, Chem. Rev., 105, 3095 (2005); https://doi.org/10.1021/cr030009u.
M. Sathishkumar, P. Shanmugavelan, S. Nagarajan, M. Dinesh and A. Ponnuswamy, New J. Chem., 37, 488 (2013); https://doi.org/10.1039/C2NJ40733G.
S. Zangade, S. Mokle, A. Vibhute and Y. Vibhute, Chem. Sci. J., 2, 1 (2011).
R. Gupta, A.K. Gupta, S. Paul and P.L. Kachroo, Indian J. Chem., 34B, 61 (1995).
J.T. Li, W.Z. Yang, S.X. Wang, S.H. Li and T.S. Li, Ultrason. Sonochem., 9, 237 (2002); https://doi.org/10.1016/S1350-4177(02)00079-2.
A.T. Dinkova-Kostova, C. Abeygunawardana and P. Talalay, J. Med. Chem., 41, 5287 (1998); https://doi.org/10.1021/jm980424s.
V.J. Ram, A.S. Saxena, S. Srivastava and S. Chandra, Med. Chem. Lett., 10, 2159 (2000); https://doi.org/10.1016/S0960-894X(00)00409-1.
M. Kidwai, P. Sapra, P. Misra, R.K. Saxena and M. Singh, Bioorg. Med. Chem., 9, 217 (2001); https://doi.org/10.1016/S0968-0896(00)00245-5.
J.F. Ballesteros, M.J. Sanz, A. Ubeda, M.A. Miranda, S. Iborra, M. Paya and M.J. Alcaraz, J. Med. Chem., 38, 2794 (1995); https://doi.org/10.1021/jm00014a032.
S.H. Lee, J.X. Nan, Y.Z. Zhao, S.W. Woo, E.J. Park, T.H. Kang, G.S. Seo, Y.C. Kim and D.H. Sohn, Planta Med., 69, 990 (2003); https://doi.org/10.1055/s-2003-45143.
M. Fathimunnisa, H. Manikandan and S. Selvanayagam, J. Mol. Struct., 1099, 407 (2015); https://doi.org/10.1016/j.molstruc.2015.06.078.