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Vol. 30 No. 4 (2018): Vol 30 Issue 4

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Synthesis and Antimicrobial Activities of Chalcones and Indole Derived from Acetyl Pyridines

https://doi.org/10.14233/ajchem.2018.21124
S. Santra
Department of Chemistry, JECRC University, Jaipur-303 905, India
B. Jat
Department of Chemistry, JECRC University, Jaipur-303 905, India
P.K. Santra
Therachem Research Medilab (India) Pvt. Ltd., Sitapura, Jaipur-302 022, India

Corresponding Author(s) : S. Santra

swapna.santra@jecrcu.edu.in

Asian Journal of Chemistry, Vol. 30 No. 4 (2018): Vol 30 Issue 4

Abstract

In the present study, chalcones and indole bearing nitrogen containing heterocyclic ring such as pyridine ring have been synthesized and characterized by elemental analysis and spectral studies. Attempts were made to prepare chacones via condensation of 2-acetyl pyridines/3-acetyl pyridines/4-acetyl pyridines with substituted benzaldehydes in presence of a number of different inorganic and organic bases. Out of different bases methanolic sodium hydroxide was found best both in terms of rate of reaction and percentage of yield. Synthesized chalcones and indoles were purified by flash column chromatography under nitrogen pressure. Purity of the isolated compounds was checked by HPLC. Compounds with HPLC purity of more than 98 % have been characterized and reported. Synthesized chalcones were tested against the bacteria strains Staphylococcus aureus and E. coli with reference to the standard drug ciprofloxacin at the concentration 1 μg/mL. Synthesized chalcones were further tested against the fungal strains Aspergillus niger and Penicillium funiculosum with reference to the standard ketoconazole at the concentration 1 μg/mL.

Keywords

Acetyl pyridine Benzaldehyde Chalcone Indole Antibacterial activity Antifungal activity
Santra, S., Jat, B., & Santra, P. (2018). Synthesis and Antimicrobial Activities of Chalcones and Indole Derived from Acetyl Pyridines. Asian Journal of Chemistry, 30(4), 883–888. https://doi.org/10.14233/ajchem.2018.21124
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