Chemical Composition and Anticancer Activity of Macaranga hosei Leaves

Eva Marliana; Winni Astuti; Khemasili Kosala; Rita Hairani; Tjitjik Srie Tjahj; Mulyadi Tanjung

doi:10.14233/ajchem.2018.21004

Issue

Vol. 30 No. 4 (2018): Vol 30 Issue 4

Issue Published : February 28, 2018

This work is licensed under a Creative Commons Attribution 4.0 International License.

Chemical Composition and Anticancer Activity of Macaranga hosei Leaves

https://doi.org/10.14233/ajchem.2018.21004

Eva Marliana

Department of Chemistry, Faculty of Mathematics and Natural Science, Mulawarman University, Samarinda 75123, East Kalimantan, Indonesia

Winni Astuti

Department of Chemistry, Faculty of Mathematics and Natural Science, Mulawarman University, Samarinda 75123, East Kalimantan, Indonesia

Khemasili Kosala

Pharmacology Research Group, Faculty of Medicine, Mulawarman University, Samarinda 75123, East Kalimantan, Indonesia

Rita Hairani

Department of Chemistry, Faculty of Mathematics and Natural Science, Mulawarman University, Samarinda 75123, East Kalimantan, Indonesia

Tjitjik Srie Tjahj

Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, East Java, Indonesia

Mulyadi Tanjung

Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Airlangga University, Surabaya 60115, East Java, Indonesia

Corresponding Author(s) : Eva Marliana

eva_samarinda@yahoo.com

Asian Journal of Chemistry, Vol. 30 No. 4 (2018): Vol 30 Issue 4
Article Published : February 28, 2018

Abstract

The anticancer activity of methanolic extract and ethyl acetate fraction of Macaranga hosei leaves against HeLa cell lines were evaluated by [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (MTT) assay. Both extracts displayed anticancer activity with IC₅₀ values of 36.18 and 7.01 μM, respectively, which can be suggested that M. hosei is a great potential source of anticancer agents. In addition, two isoprenylated flavanones, 4'-O-methyl-8-isoprenyl eriodictyol (1) and 6-isoprenyl eriodictyol (2) have been isolated from ethyl acetate fraction. The structures of both compounds have been elucidated based on their spectroscopic data, including 1D and 2D NMR spectra.

Keywords

Macaranga hosei Anticancer MTT Assay Flavanones Isoprenylated

Marliana, E., Astuti, W., Kosala, K., Hairani, R., Srie Tjahj, T., & Tanjung, M. (2018). Chemical Composition and Anticancer Activity of Macaranga hosei Leaves. Asian Journal of Chemistry, 30(4), 795–798. https://doi.org/10.14233/ajchem.2018.21004

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References

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J.W.F. Slik Priyono and V.P.C. Welzen, Gard. Bull. (Singapore), 52, 11 (2000).

M. Tanjung, E.H. Hakim and L.J.M. Elfahmi, Nat. Prod. Commun., 7, 1309 (2012).

Y.M. Syah, E.H. Hakim, S.A. Achmad, M. Hanafi and E.L. Ghisalberti, Nat. Prod. Commun., 4, 63 (2009).

I. Zakaria, N. Ahmat, F.M. Jaafar and A. Widyawaruyanti, Fitoterapia, 83, 968 (2012); https://doi.org/10.1016/j.fitote.2012.04.020.

M.A. Versiani, T. Diyabalanage, R. Ratnayake, C.J. Henrich, S.E. Bates, J.B. McMahon and K.R. Gustafson, J. Nat. Prod., 74, 262 (2011); https://doi.org/10.1021/np100797y.

W. Agustina, L.D. Juliawaty, E.H. Hakim and Y.M. Syah, ITB J. Sci., 44A, 13 (2012).

M. Tanjung, E.H. Hakim, D. Mujahidin, M. Hanafi and Y.M. Syah, J. Asian Nat. Prod. Res., 11, 929 (2009); https://doi.org/10.1080/10286020903302315.

Y.M. Syah and E.L. Ghisalberti, Nat. Prod. Commun., 5, 219 (2010).

M. Tanjung, D. Mujahidin and E.H. Hakim, Nat. Prod. Commun., 5, 1209 (2010).

D.S. Jang, M. Cuendet, A.D. Pawlus, L.B.S. Kardono, K. Kawanishi, N.R. Farnsworth, H.H.S. Fong, J.M. Pezzuto and A.D. Kinghorn, Phytochemistry, 65, 345 (2004); https://doi.org/10.1016/j.phytochem.2003.10.026.

B.J. Yoder, Ph.D. Dissertation, Faculty of Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA (2007).

B. Botta, G.D. Monache, P. Menendez and A. Boffi, Trends Pharmacol. Sci., 26, 606 (2005); https://doi.org/10.1016/j.tips.2005.09.012.

E. Marliana, T.S. Tjahtjandarie and M. Tanjung, J. Kimia Mulawarman, 3, 97 (2016).

E. Marliana, T.S. Tjahtjandarie and M. Tanjung, Der Pharm. Lett., 7, 153 (2015).

D.S. Yang, W.B. Peng, Y.P. Yang, K.C. Liu, X.L. Li and W.L. Xiao, Fitoterapia, 103, 187 (2015); https://doi.org/10.1016/j.fitote.2015.04.002.

D.S. Yang, J.G. Wei, W.B. Peng, S.M. Wang, C. Sun, Y.P. Yang, K.C. Liu and X.L. Li, Fitoterapia, 99, 261 (2014); https://doi.org/10.1016/j.fitote.2014.10.003.

M.Z. Fahmi, K. Ou, J. Chen, M. Ho, S. Tzing and J. Chang, RSC Advances, 4, 32762 (2014); https://doi.org/10.1039/C4RA05785F.

C. Bézivin, S. Tomasi, F. Lohézic-Le Dévéhat and J. Boustie, Phytomedicine, 10, 499 (2003); https://doi.org/10.1078/094471103322331458.

S.S. Azimova and V.I. Vinogradova, “Physicochemical and Pharmacological Properties of Flavonoids in Natural CompoundsFlavonoids, Springer Science Bussiness Media, New York, p. 158 (2013).

Issue

Vol. 30 No. 4 (2018): Vol 30 Issue 4

Chemical Composition and Anticancer Activity of Macaranga hosei Leaves

Corresponding Author(s) : Eva Marliana

Abstract

Keywords

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