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Vol. 30 No. 4 (2018): Vol 30 Issue 4

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Alginate/Chitosan Nanoparticles for Improved Oral Delivery of Rifampicin: Optimization, Characterization and in vitro Evaluation

https://doi.org/10.14233/ajchem.2018.20904
Deepa Thomas
Research and Post Graduate Department of Chemistry, Bishop Moore College, Mavelikara-690 110, India; Department of Chemistry, Sree Narayana College, Kollam-691 001, India
M.S. Latha
Department of Chemistry, Sree Narayana College, Kollam-691 001, India; Department of Chemistry, Sree Narayana College, Chengannur-689 508, India
K. Kurien Thomas
Research and Post Graduate Department of Chemistry, Bishop Moore College, Mavelikara-690 110, India

Corresponding Author(s) : M.S. Latha

lathams2014@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 4 (2018): Vol 30 Issue 4

Abstract

Alginate/chitosan nanoparticles were synthesized by ionotropic method using natural honey as the stabilizing agent. The nanoparticles were characterized and the potential of these nanoparticles for the controlled oral delivery of antitubercular drug rifampicin was evaluated in terms of entrapment efficiency, swelling behaviour and in vitro release of the drug. Carboxyl content and in vitro cytotoxicity of the nanoparticles were also evaluated. The swelling and in vitro drug release indicates that the system undergoes pH-dependent swelling and release of drug. Drug release was very low in acidic pH and a maximum of only 20 % of the drug was released in 5 h. A sustained release of drug was observed at pH 7.4 and complete release was obtained in 8 h. Kinetics of the drug release was analyzed by fitting the experimental data into Korsmeyer-Peppas equation and show that the mechanism involved in the release was non-Fickian, controlled by a combined mechanism of diffusion and polymer relaxation. This study shows that the obtained nanoparticles can be a potential carrier for the pH controlled oral delivery of rifampicin.

Keywords

Rifampicin Sodium alginate Chitosan Nanoparticle Honey Controlled release
Thomas, D., Latha, M., & Thomas, K. K. (2018). Alginate/Chitosan Nanoparticles for Improved Oral Delivery of Rifampicin: Optimization, Characterization and in vitro Evaluation. Asian Journal of Chemistry, 30(4), 736–740. https://doi.org/10.14233/ajchem.2018.20904
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