Synthesis and Studies on Antidepressant Effect of 5,7-Dihydroxyflavanone Derivatives
Corresponding Author(s) : Li-Ping Guan
glp730@zjou.edu.cn
Asian Journal of Chemistry,
Vol. 23 No. 3 (2011): Vol 23 Issue 3
Abstract
A series of 5,7-dihydroxyflavanone derivatives were synthesized and evaluated their antidepressant activities. The results showed that of nine compounds significantly reduced times during the forced swimming test at a dose of 10 mg/kg, indicative of antidepressant activity. Among the compounds, 4o (4′-methoxy-5,7,3′-trihydroxyflavanone) was found to be the most potent and it was observed that the compound 4o at dose of 10, 20 and 40 mg/kg significantly reduced the duration of immobility times in the Forced swimming test in mice 0.5 h after treatment.
Keywords
Synthesis
Antidepressant activity
5,7-Dihydroxyflavanone derivatives
Zhao, D.-H., Sui, X., Qu, Y.-L., Yang, L.-Y., Wang, X., & Guan, L.-P. (2010). Synthesis and Studies on Antidepressant Effect of 5,7-Dihydroxyflavanone Derivatives. Asian Journal of Chemistry, 23(3), 1129–1132. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16113
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