Synthesis, Characterization and Biological Activity of Vanadium(V) Complexes of 4-n-Hexyloxybenzoylhydrazine

Abstract

A series μ-oxo-di-vanadium(V)) complexes [(C₆H₁₃OC₆H₄C(-O)NN=CHR)₄V₂O₃] (10-17) was prepared by the reaction of vanadyloxy(IV) sulphate pentahydrate with some Schiff's bases [C₆H₁₃OC₆H₄C(=O)NH-N=CHR] (1-9) [where R = formaldehyde, acetaldehyde, butyraldehyde, crotonaldehyde, benzaldehyde, cinnamaldehyde, 4-N,N-dimethylaminobenzaldehyde, 4-methoxybanzaldehyde and 2-hydroxybenzaldehyde, respectively]. The Schiff's bases were characterized by physico-chemical techniques like IR, ¹H NMR and UV-visible spectroscopic techniques. The complexes were also characterized by using IR, ¹H NMR, TGA, magnetic moment and molar conductance. All the ligands coordinated with the VO₂(II) ion in a uninegative bidentate mode giving six coordinated oxobridged bimolecular complexes. The antibacterial screening of the complexes indicated that complex 10-13 and 16 showed antibacterial activity but the other complexes did not show any activity as compared to a standard drug (canamycin). Further more complex 10 showed low activity against Bacillus sereus, Shigella boydii, Saccharromyces cerevaceae, Candida albicans and Aspergillus niger and complex 13 showed low activity against Bacillius subtilis, Escherichia coli, Sarcina lutea and Shigella boydii bacteria. In contrast, complex 11 and 12 showed low activity whereas complex 16 showed moderate activity against all the bacteria.