Synthesis and Evaluation of Some 2-[(Substituted) ethanoyl]amino- 5-aryl-1,3,4-thiadiazoles as Diuretic Agents
Corresponding Author(s) : Sanmati K. Jain
sanmatijain72@yahoo.co.in
Asian Journal of Chemistry,
Vol. 23 No. 3 (2011): Vol 23 Issue 3
Abstract
Twelve 2-[(substituted)ethanoyl]amino-5-aryl-1,3,4-thiadiazoles were prepared by the reaction of 2-(chloro ethanoyl)amino-5-aryl-1,3,4-thiadiazoles and various secondary amines. These compounds were screened for diuretic activity. The compounds namely 4a1, 4b2 and 4c2 showed good diuretic activity comparable with the standard drug acetazolamide at a dose level of 100 mg/kg, orally in albino rats.
Keywords
Synthesis
Substituted thiadiazoles
Diuretic agents
K. Jain, S., & Mishra, P. (2010). Synthesis and Evaluation of Some 2-[(Substituted) ethanoyl]amino- 5-aryl-1,3,4-thiadiazoles as Diuretic Agents. Asian Journal of Chemistry, 23(3), 1305–1308. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16084
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