Infrared and Differential Scanning Calorimetric Studies on Solid Lipid Nanoparticles of Aceclofenac

Abstract

Solid lipid nanoparticles are particles produced by high pressure homogenization or other suitable technique having photon correlation spectroscopy diameters between 80-1000 nm. Aceclofenac is a NSAID which acts by inhibiting the secretion of tissue necrosis factor and interleukin-1. Stable solid lipid nanoparticles of this drug were prepared using different lipids namely cetyl alcohol, glyceryl palmitostearate and glyceryl behenate by Gasco microemulsion method. Batches were prepared as per Taguchi experimental design. In order to ascertain the status of drug and lipid inside solid lipid nanoparticles, infrared spectroscopic studies are required. Differential scanning calorimetric studies are done to check the amorphous/crystalline state of drug. Solid lipid nanoparticles were characterized on the basis of infrared, differential scanning calorimetric and photon correlation spectroscopy.