Total Synthesis of Monocyclic Pyrimidinium Betaines With Fatty Alkyl Chains
Fatiha Malki
Laboratoire de Recherche sur les Produits Bioactifs et Valorisation de la Biomasse, Ecole Normale Supérieure, B.P. 92, Vieux-Kouba, Algiers, Algeria
Abdelkader Touati
Laboratoire de Recherche sur les Produits Bioactifs et Valorisation de la Biomasse, Ecole Normale Supérieure, B.P. 92, Vieux-Kouba, Algiers, Algeria
Said Rahal
Laboratoire de Synthèse Organique, Faculté de Chimie, U.S.T.H.B., B.P. 32, El-Alia, 16111 Bab Ezzouar, Algiers, Algeria
Saad Moulay
Laboratoire de Chimie-Physique Moléculaire et Macromoléculaire, Département de Chimie Industrielle, Faculté des Sciences de L'Ingénieur, Université Saâd Dahlab de Blida, B. P. 270, Route de Soumâa, 09000 Blida, Algeria
Corresponding Author(s) : Saad Moulay
polymchemlab@hotmail.com
Asian Journal of Chemistry,
Vol. 23 No. 3 (2011): Vol 23 Issue 3
Seven betaines were prepared by condensation of N,N'-diphenylamidines with malonic acid derivatives. The amidines were made via a multistep synthesis, starting from their corresponding fatty acids. Malonyl chloride and dipentachlorophenyl phenylmalonate, two derivatives of malonic acid, were obtained from malonic acid and benzyl chloride, respectively. Most of the products were characterized by IR, UV, 1H and 13C NMR. Biological assays of the synthesized betaines revealed their good antibacterial and antifungal activities against the Pseudomonas aeruginosa, Bacillus subtilis and Mucor ramannianus and an activity against Candida albicans.
Malki, F., Touati, A., Rahal, S., & Moulay, S. (2010). Total Synthesis of Monocyclic Pyrimidinium Betaines With Fatty Alkyl Chains. Asian Journal of Chemistry, 23(3), 961–967. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/16067
