Microwave-Assisted Synthesis of 2,4,5-Triphenyl-1H-imidazole Containing Schiff Base Derivatives with Potential Antioxidant and Anticancer Activities

Abstract

2-(2,4,5-Triphenyl-1H-imidazol-1-yl)acetohydrazide (3) was utilized as key intermediate for the synthesis of some new Schiff bases 4a-k and 5 under reflux temperature as well as microwave irradiation. All the synthesized compounds were characterized by IR, ¹H NMR, ¹³C NMR and HRMS spectral studies. The antioxidant and anticancer activities of these newly synthesized Schiff base derivatives containing 2,4,5-triphenyl-1H-imidazole moiety have been evaluated.