Screening and Identification of Multi Compounds in Radix aconiti Using Combination of Liquid Chromatography/Time-of-Flight Tandem Mass Spectrometry

Abstract

An approach for screening and identification of multi components in traditional Chinese medicine systems using combination of LC/TOF-MS technique was described in this paper. The chemical profile of Radix A., a well-known traditional Chinese medicine, was studied using the established method as for an application and the possibilities of screening complex traditional Chinese medicine systems and identifying these non-target components with modern data acquisition methods of acceleration time of flight mass spectrometers, such as data-dependent MS to MS/ MS switching were investigated. As a result, 33 components were identified. This study is expected to provide a rapid, sensitive, economical and systematical method for the identification and further quality evaluation of traditional Chinese medicine.