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Vol. 24 No. 1 (2012): Vol 24 Issue 1

Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones Using Molybdenum(V) Chloride as a Catalyst

M. Adharvana Chari
Dr. MACS Bio-Pharma Pvt. Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-500 085, India; Department of Complexity Science and Engineering, School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa, Chiba 277-8561, Japan
D. Shobha
Dr. MACS Bio-Pharma Pvt. Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-500 085, India ; Department of Complexity Science and Engineering, School of Frontier Sciences, The University of Tokyo, 5-1-5, Kashiwanoha, Kashiwa, Chiba 277-8561, Japan
S. Parameswari
Dr. MACS Bio-Pharma Pvt. Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-500 085, India
Banala Ramesh
Dr. MACS Bio-Pharma Pvt. Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-500 085, India
R.R. Pal
Dr. MACS Bio-Pharma Pvt. Ltd., Plot No. 32/A, Western Hills, Kukatpally, Hyderabad-500 085, India

Corresponding Author(s) : M. Adharvana Chari

drmac_s@yahoo.com

Asian Journal of Chemistry, Vol. 24 No. 1 (2012): Vol 24 Issue 1

Abstract

Molybdenum(V)chloride catalyzes efficiently the three component condensation reaction of aldehyde, b-ketoester and urea in refluxing acetonitrile to afford the corresponding dihydropyrimidinones (DHPMs). Compared to the classical Biginelli reaction conditions, this new approach consistently has the advantage of excellent yields (80-91 %) and short reaction times 1.4-2.6 h.

Keywords

Aldehyde Urea and thiourea Molybdenum(V)chloride Dihydropyrimidinones b-Ketoester
(1)
Adharvana Chari, M.; Shobha, D.; Parameswari, S.; Ramesh, B.; Pal, R. Synthesis of 3,4-Dihydropyrimidin-2(1H)-Ones Using Molybdenum(V) Chloride As a Catalyst. ajc 2011, 24, 15-17.
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