Synthesis, Characterization and Biological Activity of Fe(II), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II) Complexes of Tridentate Thiosemicarbazones

Abstract

Metal complexes of divalent d-block metal ions with different thiosemicarbazones have been synthesized. These thiosemicarbazone ligands forms complexes with iron(II), cobalt(II), nickel(II), copper(II), zinc(II), cadmium(II) and mercury(II). The structural study of the complexes have been characterized by elemental analysis, conductance, IR, NMR and Mass spectral data. The physico-chemical and spectral data suggests octahedral and tetrahedrol geometry for various complexes. The ligand and metal chelates have been screened in vitro for antimicrobial activity against some of the fungal and bacterial. The screening have revealed that metal complexes exhibit enhanced activity than their parent ligand-against both the fungal and bacterial strains used.