Determination of Azithromycin by Extractive Spectrophotometry

Abstract

Two simple extractive spectrophotometric methods (M₁ and M₂) are developed for the determination of azithromycin (AZ) in bulk and dosage forms. They are based on the formation of coloured species with wool fast blue BL (WFBBL, M₁) and tropileon 000 (TPOOO M₂) reagents exhibiting maximum absorption at 580 and 480 nm, respectively. Methods M₁ and M₂ obeyed Beer's law limits 5-25 μg mL^-1 and 10-40 μg mL^-1, respectively. The proposed methods are simple, selective, sensitive and economical for the routine qualitative and quantitative determination of azithromycin in pharmaceutical formulations.