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Vol. 23 No. 2 (2011): Vol 23 Issue 2

Phytochemical and Antimicrobial Activities of Two New Novel Bioactive Analogues of Subergorgic Acid from Subergorgia suberosa

G. Damodar Reddy
Department of Organic Chemistry, School of Chemistry, Andhra University, Visakhapatnam530 003, India
D. Rama Sekhara Reddy
Department of Organic Chemistry, School of Chemistry, Andhra University, Visakhapatnam530 003, India ; Present address: Institute of Biological Chemistry, Washington State University, Pullman, WA 99164-6340, USA
A. Razzack
Department of Organic Chemistry, School of Chemistry, Andhra University, Visakhapatnam530 003, India
K. Balaji
Department of Organic Chemistry, School of Chemistry, Andhra University, Visakhapatnam530 003, India

Corresponding Author(s) : G. Damodar Reddy

damodarau@gmail.com; dachuru@gmail.com

Asian Journal of Chemistry, Vol. 23 No. 2 (2011): Vol 23 Issue 2

Abstract

A series of bioactive analogues were synthesized from subergorgic acid 1, a cardiotoxic marine metabolite. Two new compounds, 2 and 7 have been synthesized in high yields by the NaBH4 reduction of subergorgic acid 1 and its methyl ester 6, respectively. The structures of new compounds have been determined by spectroscopic methods. The reductions have given the known compounds 3 and 4 as minor products. All these compounds 1, 2, 4, 6 and 7 showed a significant level of antifungal properties.

Keywords

Subergorgic acid Diterpene Subergorgia suberosa Marine metabolite
Damodar Reddy, G., Rama Sekhara Reddy, D., Razzack, A., & Balaji, K. (2010). Phytochemical and Antimicrobial Activities of Two New Novel Bioactive Analogues of Subergorgic Acid from Subergorgia suberosa. Asian Journal of Chemistry, 23(2), 816–818. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/15900
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