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Vol. 30 No. 3 (2018): Vol 30 Issue 3

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Quantitative Structure Activity Relationship and Biological Activity Studies of 4-Methyl-2-(4-substituted phenyl)quinoline Derivatives

https://doi.org/10.14233/ajchem.2018.20811
P.K. Rahangdale
Department of Chemistry, Bhawabhuti College, Amgaon-441 902, India
F. Inam
Department of Chemistry, Government Vidarbha Institute of Science and Humanities, Amravati-441 604, India
S.S. Chourasia
Department of Chemistry, M.B. Patel College, Deori-441 901, India

Corresponding Author(s) : P.K. Rahangdale

pralhadrahangdale@gmail.com

Asian Journal of Chemistry, Vol. 30 No. 3 (2018): Vol 30 Issue 3

Abstract

Quantitative structure activity relationship (QSAR) studies of some 4-methyl-2-(4-substituted phenyl)quinoline derivatives were carried out to determine their predicted biological activities. Numbers of descriptors were tested to adjudge a quantitative correlation between activity and structural features using training set and test set. Significant correlation was observed between activities and descriptors. The results were interpreted on the basis of linear regression analysis. Experimental antibacterial activities of the test set compounds were determined. The predicted biological activities generated by QSAR model were compared with the experimental antibacterial activities. The concurrence between the predicted and experimental biological activities validates the QSAR model. Thus, it can be concluded that the model under the present investigation can be applied for predicting the unknown biological activities of structurally similar molecules.

Keywords

Quantitative structure activity relationship Quinoline derivatives Biological activity
Rahangdale, P., Inam, F., & Chourasia, S. (2018). Quantitative Structure Activity Relationship and Biological Activity Studies of 4-Methyl-2-(4-substituted phenyl)quinoline Derivatives. Asian Journal of Chemistry, 30(3), 479–482. https://doi.org/10.14233/ajchem.2018.20811
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