Copyright (c) 2018 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Determination of Palladium Content in Nebivolol HCl Bulk Drug by ICP-OES
Corresponding Author(s) : B. Siva Sai Kiran
Asian Journal of Chemistry,
Vol. 30 No. 1 (2018): Vol 30 Issue 1
Abstract
The aim of the present work is to develop a validated analytical method for the determination of palladium content in nebivolol HCl bulk drug by inductive coupled plasma-optical emission spectroscopy (ICP-OES). Samples were analyzed after a preparation of sample solution by dissolving in suitable diluents of nitric acid along with hydrogen peroxide. In the present method, RF power of 1500 watts, plasma flow of 15 L/min, nebulizer flow of 0.7 L/min and plasma view at axial mode were used. The wavelength was monitored at 340.46 nm. This allowed a rapid determination of amount of palladium metal present in nebivolol bulk drug. The developed method was validated according to ICH guidelines. Calibration curve for palladium determination were conducted in the range of 10-100 μg/mL. The correlation coefficient for palladium was found to be 0.999970 which indicates good linearity. Recovery rates for palladium were in the range of 86.66-102.66. Limit of detection (LOD) and limit of quantification (LOQ) present in the sample was found to be 3 μg/mL and 10 μg/mL, respectively. The method developed and validated was selective, sensitive, rapid and capable of detecting palladium in the presence of other elements in bulk drugs.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- H. Ryakala, S. Dineshmohan, A. Ramesh and V.R.M. Gupta, J. Drug Deliv., Article ID 827859 (2015); https://doi.org/10.1155/2015/827859.
- R.A. De Boer, A.A. Voors and D.J. van Veldhuisen, Expert Opin. Pharmacother., 8, 1539 (2007); https://doi.org/10.1517/14656566.8.10.1539.
- M.J. Tafreshi and A.B. Weinacker, Pharmacotherapy, 19, 974 (1999); https://doi.org/10.1592/phco.19.11.974.31575.
- E. Agabiti Rosei and D. Rizzoni, Drugs, 67, 1097 (2007); https://doi.org/10.2165/00003495-200767080-00001.
- R. Weiss, Vasc. Health Risk Manag., 2, 303 (2006); https://doi.org/10.2147/vhrm.2006.2.3.303.
- G. Bakris, J. Cardiovasc. Pharmacol., 53, 379 (2009); https://doi.org/10.1097/FJC.0b013e31819fd501.
- T. Münzel and T. Gori, J. Am. Coll. Cardiol., 54, 1491 (2009); https://doi.org/10.1016/j.jacc.2009.05.066.
- C.B. Boss and J.F. Kenneth, Concepts, Instrumentation and Techniques in Inductively Coupled Plasma Optical Emission Spectrometry, Bridgeport Avenue Shelton, CT: Perkin Elmer (2004).
- A.A. Bayizit and M. Tarun, Not. Bot. Hort. Agrobot. Cluj, 38, 64 (2010).
- V. Nikolaya, O. Veleva, S. Velichkov and N. Daskalova, J. Spectrosc., Article ID 505871 (2013); https://doi.org/10.1155/2013/505871.
- Y. Yamini, M. Rezaee, A. Khanchi, M. Faraji and A. Saleh, J. Chromatogr. A, 1217, 2358 (2010); https://doi.org/10.1016/j.chroma.2009.11.046.
- M. Bettinelli, G.M. Beone, S. Spezia and C. Baffi, Anal. Chim. Acta, 424, 289 (2000); https://doi.org/10.1016/S0003-2670(00)01123-5.
- M. Rezaee, Y. Yamini, A. Khanchi, M. Faraji and A. Saleh, J. Hazard. Mater., 178, 766 (2010); https://doi.org/10.1016/j.jhazmat.2010.02.006.
- C. Huang, B. Hu and Z. Jiang, Spectrochim. Acta B At. Spectrosc., 62, 454 (2007); https://doi.org/10.1016/j.sab.2007.04.012.
- S.L. Ferreira,A.S. Queiroz, M.S. Fernandes and H.C. dos Santos, Spectrochim. Acta B At. Spectrosc., 57, 1939 (2002); https://doi.org/10.1016/S0584-8547(02)00160-X.
- M. Faraji, Y. Yamini,A. Saleh, M. Rezaee, M. Ghambarian and R. Hassani, Anal. Chim. Acta, 659, 172 (2010); https://doi.org/10.1016/j.aca.2009.11.053.
- M.A. Al-Rajhi, J. Anal. Sci. Methods Instr., 4, 46 (2014); https://doi.org/10.4236/jasmi.2014.42007.
- M.R.F. Tehrani, A. Shamsai and M. Vossughi, J. Environ. Health Sci. Eng., 13, 1 (2015); https://doi.org/10.1186/s40201-015-0157-3.
- V.V. Vallapragada, G. Inti and J.S. Ramulu, Am. J. Anal. Chem., 2, 718 (2011); https://doi.org/10.4236/ajac.2011.26082.
- V. Mamatha and J. Kumar Raja, J. Adv. Pharm. Edu. Res., 3, 516 (2013).
References
H. Ryakala, S. Dineshmohan, A. Ramesh and V.R.M. Gupta, J. Drug Deliv., Article ID 827859 (2015); https://doi.org/10.1155/2015/827859.
R.A. De Boer, A.A. Voors and D.J. van Veldhuisen, Expert Opin. Pharmacother., 8, 1539 (2007); https://doi.org/10.1517/14656566.8.10.1539.
M.J. Tafreshi and A.B. Weinacker, Pharmacotherapy, 19, 974 (1999); https://doi.org/10.1592/phco.19.11.974.31575.
E. Agabiti Rosei and D. Rizzoni, Drugs, 67, 1097 (2007); https://doi.org/10.2165/00003495-200767080-00001.
R. Weiss, Vasc. Health Risk Manag., 2, 303 (2006); https://doi.org/10.2147/vhrm.2006.2.3.303.
G. Bakris, J. Cardiovasc. Pharmacol., 53, 379 (2009); https://doi.org/10.1097/FJC.0b013e31819fd501.
T. Münzel and T. Gori, J. Am. Coll. Cardiol., 54, 1491 (2009); https://doi.org/10.1016/j.jacc.2009.05.066.
C.B. Boss and J.F. Kenneth, Concepts, Instrumentation and Techniques in Inductively Coupled Plasma Optical Emission Spectrometry, Bridgeport Avenue Shelton, CT: Perkin Elmer (2004).
A.A. Bayizit and M. Tarun, Not. Bot. Hort. Agrobot. Cluj, 38, 64 (2010).
V. Nikolaya, O. Veleva, S. Velichkov and N. Daskalova, J. Spectrosc., Article ID 505871 (2013); https://doi.org/10.1155/2013/505871.
Y. Yamini, M. Rezaee, A. Khanchi, M. Faraji and A. Saleh, J. Chromatogr. A, 1217, 2358 (2010); https://doi.org/10.1016/j.chroma.2009.11.046.
M. Bettinelli, G.M. Beone, S. Spezia and C. Baffi, Anal. Chim. Acta, 424, 289 (2000); https://doi.org/10.1016/S0003-2670(00)01123-5.
M. Rezaee, Y. Yamini, A. Khanchi, M. Faraji and A. Saleh, J. Hazard. Mater., 178, 766 (2010); https://doi.org/10.1016/j.jhazmat.2010.02.006.
C. Huang, B. Hu and Z. Jiang, Spectrochim. Acta B At. Spectrosc., 62, 454 (2007); https://doi.org/10.1016/j.sab.2007.04.012.
S.L. Ferreira,A.S. Queiroz, M.S. Fernandes and H.C. dos Santos, Spectrochim. Acta B At. Spectrosc., 57, 1939 (2002); https://doi.org/10.1016/S0584-8547(02)00160-X.
M. Faraji, Y. Yamini,A. Saleh, M. Rezaee, M. Ghambarian and R. Hassani, Anal. Chim. Acta, 659, 172 (2010); https://doi.org/10.1016/j.aca.2009.11.053.
M.A. Al-Rajhi, J. Anal. Sci. Methods Instr., 4, 46 (2014); https://doi.org/10.4236/jasmi.2014.42007.
M.R.F. Tehrani, A. Shamsai and M. Vossughi, J. Environ. Health Sci. Eng., 13, 1 (2015); https://doi.org/10.1186/s40201-015-0157-3.
V.V. Vallapragada, G. Inti and J.S. Ramulu, Am. J. Anal. Chem., 2, 718 (2011); https://doi.org/10.4236/ajac.2011.26082.
V. Mamatha and J. Kumar Raja, J. Adv. Pharm. Edu. Res., 3, 516 (2013).