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Synthesis, Characterization and Biological Applications of Random Aliphatic Copolythioesters Using 3,3'-Thiodipropionic Acid
Corresponding Author(s) : Kosinapogu Sudhakar
Asian Journal of Chemistry,
Vol. 30 No. 1 (2018): Vol 30 Issue 1
Abstract
The aliphatic random copolyester polycyclohexylthiodipropionate-co-cyclohexyldecanedioate (PCTCD) containing sulphur atom in the main chain was synthesized by mixing 3,3’-thiodipropionic acid, decanedioic acid and 1,4-cyclohexanediol monomers with titanium tetra isopropoxide catalyst using direct melt polycondensation method. The different physical properties of copolyester such as inherent viscosity, solubility, differential scanning colorimetry and X-ray diffraction technique was investigated. The chemical structure of the copolyester was investigated by FTIR, 1H NMR and 13C NMR spectroscopy. The synthesized compounds were tested for human pathogenic bacteria using well diffusion method, in vitro cytotoxicity against normal (Vero cell line) and cancer (A549 lung cancer cell line) by MTT assay. Also in vitro antioxidant property of copolymer was studied.
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References
A. Steinbuchel, T. Lutke-Eversloh and C. Ewering, Sulfur Containing Polyhydroxyalkanoate Compositions and Method of Production, US Patent 6495152 B2 (2002).
H.F. Mark, Encylopedia of Polymer Science and Technology Concise, John Wiley & Sons, edn 3, pp. 1169 (2013).
A. Steinbüchel, H. Luftmann, K. Bergander and T. Lütke-Eversloh, Microbiology, 147, 11 (2001); https://doi.org/10.1099/00221287-147-1-11.
E. Fehling, E. Klein, K. Vosmann, K. Bergander and N. Weber, Biotechnol. Bioeng., 99, 1074 (2008); https://doi.org/10.1002/bit.21704.
M.S. Blois, Nature, 181, 1199 (1958); https://doi.org/10.1038/1811199a0.
C. Perez, M. Pauli and P. Bazerque, Acta Biol. Med. Exp., 15, 113 (1958).
T. Mosmann, J. Immunol. Methods, 65, 55 (1983); https://doi.org/10.1016/0022-1759(83)90303-4.