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Chemical Composition and Pharmacological Activities of Plantago major L. in Vietnam

https://doi.org/10.14233/ajchem.2021.22976
Do Thi Viet Huong
VNU University of Science, Vietnam National University, Hanoi, Vietnam
Phan Minh Giang
VNU University of Science, Vietnam National University, Hanoi, Vietnam
Do Huy Hoang
VNU University of Science, Vietnam National University, Hanoi, Vietnam
Nguyen Anh Phuong
Hanoi National University of Education, Hanoi, Vietnam
Trieu Anh Trung
Hanoi National University of Education, Hanoi, Vietnam

Corresponding Author(s) : Do Thi Viet Huong

dothiviethuong@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 2 (2021): Vol 33 Issue 2

Abstract

Plantago major L. in Vietnam was investigated for its chemical composition and also evaluated the biological activities against enzyme α-glucosidase and free radicals activities. The powder mixture of dried leave and roots of this species was extracted separately by three solvents: dichloromethane, water, water:alcohol (50:50, v:v). The chemical composition of dichloromethane extract was analyzed by GC-MS system to identify eighteen components, out of which eight biologically active compounds viz. 5-hydroxymethylfurfural, n-hecxadecanoic acid, 9,12-octadecadienoic acid (Z,Z)-methyl ester, allogibberic acid, β-tocopherol, campesterol, γ-sitosterol, lup-20(29)-en-3-ol and friedenlan-3-one were presented. The concentration of radical scavenging activity DPPH expressed by IC50 for water, water:alcohol (50:50, v:v) and dichloromethane with 208.7, 89.3 and 62.05 μg/mL, respectively. The dichloromethane, water and water:alcohol (50:50, v:v) extract of Plantago major exhibited α-glucosidase inhibitory activity with IC50 values of 116.4, 302.7, 195.9 μg/mL, respectively, which was comparable with acarbose (98.4 μg/mL). Plantago major L. in Vietnam may be effective inhibitors as the antidiabetic candidate and helpful to reduce the postprandial glucose levels.

Keywords

Plantago major L. Radical scavenging activity α-Glucosidase inhibitory activity GC-MS
Thi Viet Huong, D., Minh Giang, P., Huy Hoang, D., Anh Phuong, N., & Anh Trung, T. (2021). Chemical Composition and Pharmacological Activities of Plantago major L. in Vietnam. Asian Journal of Chemistry, 33(2), 314–318. https://doi.org/10.14233/ajchem.2021.22976
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