Copyright (c) 2021 AJC
This work is licensed under a Creative Commons Attribution 4.0 International License.
Synthesis and Antimicrobial Studies of Novel N-Glycosyl Hydrazino Carbothioamide
Asian Journal of Chemistry,
Vol. 33 No. 1 (2021): Vol 33 Issue 1
Abstract
In view of applications of N-glycosylated compounds in medicinal chemistry and in many other ways, herein the synthesis of novel N-glycosyl hydrazino carbothioamides is reported. New N-glycosyl hydrazino carbothioamides were synthesized by the condensation of per-O-acetyl glycosyl isothiocyanate with different aromatic hydrazides. The newly synthesized compounds were characterized by using the IR, 1H NMR and mass spectral studies. Antimicrobial evaluation of the synthesized N-glycosyl hydrazino carbothioamide was also examined. Antimicrobial activities of the synthesized compound were evaluated against bacteria E. coli, P. aeruginosa, S. aureus, S. pyogenus and fungi C. albicans, A. niger and A. clavatus. All the N-glycosyl hydrazino carbothioamides exhibit promising antimicrobial activity.
Keywords
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
- J.M.G. Fernández and C.O. Mellet, Adv. Carbohydr. Chem. Biochem., 55, 35 (2000); https://doi.org/10.1016/S0065-2318(00)55004-5
- C. Prata, N. Mora, J.M. Lacombe, J.C. Maurizis and B. Pucci, Carbohydr. Res., 321, 4 (1999);https://doi.org/10.1016/S0008-6215(99)00161-5
- M.M. De Oliveira, M.C.F. Linardi and M.R.P. Sampaio, J. Pharm. Sci.,67, 562 (1978); https://doi.org/10.1002/jps.2600670435
- A. Saeed, H. Rafique, A. Hameed and S. Rasheed, Pharm. Chem. J., 42,191 (2008); https://doi.org/10.1007/s11094-008-0094-x
- D. Kumari, H. Bansal, Pharma Innov. J., 7, 543 (2018).
- L. McNeill, M. Allen, C. Estrada and P. Cook, Chest, 123, 102 (2003); https://doi.org/10.1378/chest.123.1.102
- M.C.S. Lourenço, M.V.N. Souza, A.C. Pinheiro, M.L. Ferreira, R.S.B.Gonçalves, T.C.M. Nogueira and M.A. Peralta, ARKIVOC, 181 (2007); https://doi.org/10.3998/ark.5550190.0008.f18
- K.R. Paidi, V.B. Tatipamula, M.K. Kolli and V.R. Pedakotla, Int. J. Chem. Sci., 15, 172 (2017).
- A.S. Dandale, D.V. Mangte and S.P. Deshmukh, Carbohydr. Res., 342,753 (2007); https://doi.org/10.1016/j.carres.2006.11.025
- A.S. Dandale and S.P. Deshmukh, Indian J. Chem., 47B, 613 (2008).
- A.S. Dandale, D.V. Mangte and S.P. Deshmukh, J. Korean Chem. Soc.,54, 287 (2010); https://doi.org/10.5012/jkcs.2010.54.3.287
- A.S. Dandale and S.P. Deshmukh, Pharm. Chem. J., 45, 369 (2011); https://doi.org/10.1007/s11094-011-0636-5
- A.D. Mangte, S.J. Munshi and R.P. Nayak, Int. J. Pharm. Sci. Res., 10, 4552 (2019); https://doi.org/10.13040/IJPSR.0975-8232.10(10).4552-56
- NCCLS (National Committee for Clinical Laboratory Standards), Performance Standards for Antimicrobial Susceptibility Testing: Twelfth Informational Supplement, M100-S12 (M7) (2002).
References
J.M.G. Fernández and C.O. Mellet, Adv. Carbohydr. Chem. Biochem., 55, 35 (2000); https://doi.org/10.1016/S0065-2318(00)55004-5
C. Prata, N. Mora, J.M. Lacombe, J.C. Maurizis and B. Pucci, Carbohydr. Res., 321, 4 (1999);https://doi.org/10.1016/S0008-6215(99)00161-5
M.M. De Oliveira, M.C.F. Linardi and M.R.P. Sampaio, J. Pharm. Sci.,67, 562 (1978); https://doi.org/10.1002/jps.2600670435
A. Saeed, H. Rafique, A. Hameed and S. Rasheed, Pharm. Chem. J., 42,191 (2008); https://doi.org/10.1007/s11094-008-0094-x
D. Kumari, H. Bansal, Pharma Innov. J., 7, 543 (2018).
L. McNeill, M. Allen, C. Estrada and P. Cook, Chest, 123, 102 (2003); https://doi.org/10.1378/chest.123.1.102
M.C.S. Lourenço, M.V.N. Souza, A.C. Pinheiro, M.L. Ferreira, R.S.B.Gonçalves, T.C.M. Nogueira and M.A. Peralta, ARKIVOC, 181 (2007); https://doi.org/10.3998/ark.5550190.0008.f18
K.R. Paidi, V.B. Tatipamula, M.K. Kolli and V.R. Pedakotla, Int. J. Chem. Sci., 15, 172 (2017).
A.S. Dandale, D.V. Mangte and S.P. Deshmukh, Carbohydr. Res., 342,753 (2007); https://doi.org/10.1016/j.carres.2006.11.025
A.S. Dandale and S.P. Deshmukh, Indian J. Chem., 47B, 613 (2008).
A.S. Dandale, D.V. Mangte and S.P. Deshmukh, J. Korean Chem. Soc.,54, 287 (2010); https://doi.org/10.5012/jkcs.2010.54.3.287
A.S. Dandale and S.P. Deshmukh, Pharm. Chem. J., 45, 369 (2011); https://doi.org/10.1007/s11094-011-0636-5
A.D. Mangte, S.J. Munshi and R.P. Nayak, Int. J. Pharm. Sci. Res., 10, 4552 (2019); https://doi.org/10.13040/IJPSR.0975-8232.10(10).4552-56
NCCLS (National Committee for Clinical Laboratory Standards), Performance Standards for Antimicrobial Susceptibility Testing: Twelfth Informational Supplement, M100-S12 (M7) (2002).