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Vol. 33 No. 1 (2021): Vol 33 Issue 1

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Advanced Dosage Form Design: Role of Modified Natural Gums: A Review

https://doi.org/10.14233/ajchem.2021.22937
Gayatri Devi
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala Highway, Rajpura-140401, India
Malkiet Kaur
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala Highway, Rajpura-140401, India
Manju Nagpal
Chitkara College of Pharmacy, Chitkara University, Chandigarh-Patiala Highway, Rajpura-140401, India
Ameya Sharma
Chitkara University School of Pharmacy, Chitkara University, Bratiwala Baddi-174103, India
Vivek Puri
Chitkara University School of Pharmacy, Chitkara University, Bratiwala Baddi-174103, India
Gitika Arora Dhingra
NCRD′s Sterling Institute of Pharmacy, Nerul, Navi Mumbai-400706, India
Minaxi Arora
Department of Pharmacy, Shree Lakshmi Narayan Ayurvedic College, Amritsar-143006, India

Corresponding Author(s) : Manju Nagpal

manju.nagpal@chitkarauniversity.edu.in; nagpalmanju@ymail.com

Asian Journal of Chemistry, Vol. 33 No. 1 (2021): Vol 33 Issue 1

Abstract

Gums are naturally occurring segments in plants, which are cheap and abundant. Natural gums and their derivatives are widely used in a pharmaceutical dosage form. These natural materials possess several advantages over synthetic ones being chemically inert, non-toxic, low cost and biodegradable. However, quick degradation in the body, poor mechanical properties and low solubility are few disadvantages. To overcome these disadvantages, natural gums are modified by applying different chemical modification procedures. The modification of gums is done via various methods such as changing functional groups of gum, cross-linking with ions, grafting with polymers, sulfation, phosphorylation and thiolation. Modification of gums results in some superior properties which can be used in drug delivery applications. For example, change in crystallinity, improved solubility, stability, and improved mechanical properties are of use in development of modified drug delivery systems. Modified gums help to achieve pH dependent delivery and sustained delivery along with improved release kinetics of the drug. Current review covers various types of modifications in general and research literature on various medications of different gums (locust bean gum, cashew gum, moringa gum, xanthan gum, etc.). The modified natural gums and their derivatives can be the prospective carriers in the controlled drug delivery of drugs.

Keywords

Natural Gums Modification Cross-linking Grafting Sulfation Sustained release
Devi, G., Kaur, M., Nagpal, M., Sharma, A., Puri, V., Arora Dhingra, G., & Arora, M. (2020). Advanced Dosage Form Design: Role of Modified Natural Gums: A Review. Asian Journal of Chemistry, 33(1), 1–9. https://doi.org/10.14233/ajchem.2021.22937
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