Synthesis and Characterization of Novel Analogues of Lopinavir

Peketi Rajesh Reddy; Sivanadh Musunuri; D. Ramasekhara Reddy; V. Subrahmanyam Chittala; P.V.N.S. Murthy; K. Krishnamohan

doi:10.14233/ajchem.2021.22954

Issue

Vol. 33 No. 1 (2021): Vol 33 Issue 1

Issue Published : December 10, 2020

This work is licensed under a Creative Commons Attribution 4.0 International License.

Synthesis and Characterization of Novel Analogues of Lopinavir

https://doi.org/10.14233/ajchem.2021.22954

Peketi Rajesh Reddy

Research and Development Department, Monvi Labs, 3rd Floor, Plot No 97, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India ; Department of Chemistry, Krishna University, Machilipatnam-521001, India

Sivanadh Musunuri

Department of Chemistry, Krishna University, Machilipatnam-521001, India

D. Ramasekhara Reddy

Department of Chemistry, Krishna University, Machilipatnam-521001, India

V. Subrahmanyam Chittala

Research and Development Department, Monvi Labs, 3rd Floor, Plot No 97, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India

P.V.N.S. Murthy

Research and Development Department, Monvi Labs, 3rd Floor, Plot No 97, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India

K. Krishnamohan

Research and Development Department, Monvi Labs, 3rd Floor, Plot No 97, ALEAP Industrial Area, Gajularamaram, Hyderabad-500090, India

Corresponding Author(s) : Peketi Rajesh Reddy

rajeshpeketi1979@@gmail.com

Asian Journal of Chemistry, Vol. 33 No. 1 (2021): Vol 33 Issue 1
Article Published : December 10, 2020

Abstract

The present work describes the identification, origin, synthesis, characterization and control of four novel analogues of lopinavir viz. leucine analogue of lopinavir, isoleucine analogue of lopinavir, methyl analogue of lopinavir and dihydroxy analogue of lopinavir.

Keywords

Lopinavir Leucine Isoleucine Analogues

Rajesh Reddy, P., Musunuri, S., Ramasekhara Reddy, D., Subrahmanyam Chittala, V., Murthy, P., & Krishnamohan, K. (2020). Synthesis and Characterization of Novel Analogues of Lopinavir. Asian Journal of Chemistry, 33(1), 151–158. https://doi.org/10.14233/ajchem.2021.22954

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References

A. Chandwani and J. Shuter, Ther. Clin. Risk Manag., 4, 1023 (2008); https://doi.org/10.2147/tcrm.s3285
C. Flexner, N. Engl. J. Med., 338, 1281 (1998); https://doi.org/10.1056/NEJM199804303381808
International Conference on Harmonization (ICH) Guidelines. Q3A (R) Impurities in New Drug Substances, ICH Guidelines: Geneva, Switzerland (2002).
International Conference on Harmonization (ICH) Guidelines, Q2B Validation of Analytical Procedure: Methodology, ICH Guidelines: Geneva, Switzerland (1996).
H.L. Sham, D.A. Betebenner, T. Herrin, G. Kumar, S. Vasavanonda, A. Saldivar, A. Molla, D.J. Kempf, J.J. Plattner and W. Norbeck, Bioorg.Med. Chem. Lett., 11, 1351 (2001); https://doi.org/10.1016/S0960-894X(01)00243-8
S.R. Chitturi, Ch. Bharathi, A.V. Reddy, K.C. Reddy, H.K. Sharma, V.K. Handa, R. Dandala and V.H. Bindu, J. Pharm. Biomed. Anal., 48,1430 (2008); https://doi.org/10.1016/j.jpba.2008.09.015
H.L. Sham, C. Zhao, L. Li, D.A. Betebenner, S. Vasavanonda, D.J.Kempf, A. Saldivar, J.J. Plattner and D.W. Norbeck, Bioorg. Med. Chem.Lett., 12, 3101 (2002); https://doi.org/10.1016/S0960-894X(02)00643-1
H.L. Sham, D.A. Betebenner, X. Chen, A. Saldivar, S. Vasavanonda, D.J. Kempf, J.J. Plattner and D.W. Norbeck, Bioorg. Med. Chem. Lett.,12, 1185 (2002); https://doi.org/10.1016/S0960-894X(02)00134-8
A.V. Raghava Reddy, Sci. Pharm., 83, 49 (2015); https://doi.org/10.3797/scipharm.1407-14
H.L. Sham, D.A. Betebenner, W. Rosenbrook, T. Herrin, A. Saldivar, S. Vasavanonda, J.J. Plattner and D.W. Norbeck, Bioorg. Med. Chem. Lett.,14, 2643 (2004); https://doi.org/10.1016/j.bmcl.2004.02.089
A.S. Lakshmi Devi, Y.S. Rao, Y. Suresh, M.Y. Reddy, G. Jyothi, B. Rajababu, V.S. Prasad and V.U. Rao, Magn. Reson. Chem., 45, 424 (2007); https://doi.org/10.1002/mrc.1968
U. Seshachalam, B. Haribabu and K. Chandrasekhar, Biomed. Chromatogr., 21, 716 (2007); https://doi.org/10.1002/bmc.810
V.R.R. Ambati, S. Garaga, R. Dandala and S. Meenakshisunderam, Process for the Preparation of Substantially Pure (2S,3S,5S)-5-Amino2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane, US Patent No 8236991B (2007).
E.J. Stoner, A.J. Cooper, D.A. Dickman, L. Kolacz Kowski, J.E. Lallaman, J.H. Liu, P.A. Oliver-Shaffer, K.M. Patel, J.B. Paterson, D.J. Plata, D.A. Riley, H.L. Sham, P.J. Stengel and J.H. Tien, Org. Process Res. Dev., 4, 264 (2000);https://doi.org/10.1021/op990202j
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References

A. Chandwani and J. Shuter, Ther. Clin. Risk Manag., 4, 1023 (2008); https://doi.org/10.2147/tcrm.s3285

C. Flexner, N. Engl. J. Med., 338, 1281 (1998); https://doi.org/10.1056/NEJM199804303381808

International Conference on Harmonization (ICH) Guidelines. Q3A (R) Impurities in New Drug Substances, ICH Guidelines: Geneva, Switzerland (2002).

International Conference on Harmonization (ICH) Guidelines, Q2B Validation of Analytical Procedure: Methodology, ICH Guidelines: Geneva, Switzerland (1996).

H.L. Sham, D.A. Betebenner, T. Herrin, G. Kumar, S. Vasavanonda, A. Saldivar, A. Molla, D.J. Kempf, J.J. Plattner and W. Norbeck, Bioorg.Med. Chem. Lett., 11, 1351 (2001); https://doi.org/10.1016/S0960-894X(01)00243-8

S.R. Chitturi, Ch. Bharathi, A.V. Reddy, K.C. Reddy, H.K. Sharma, V.K. Handa, R. Dandala and V.H. Bindu, J. Pharm. Biomed. Anal., 48,1430 (2008); https://doi.org/10.1016/j.jpba.2008.09.015

H.L. Sham, C. Zhao, L. Li, D.A. Betebenner, S. Vasavanonda, D.J.Kempf, A. Saldivar, J.J. Plattner and D.W. Norbeck, Bioorg. Med. Chem.Lett., 12, 3101 (2002); https://doi.org/10.1016/S0960-894X(02)00643-1

H.L. Sham, D.A. Betebenner, X. Chen, A. Saldivar, S. Vasavanonda, D.J. Kempf, J.J. Plattner and D.W. Norbeck, Bioorg. Med. Chem. Lett.,12, 1185 (2002); https://doi.org/10.1016/S0960-894X(02)00134-8

A.V. Raghava Reddy, Sci. Pharm., 83, 49 (2015); https://doi.org/10.3797/scipharm.1407-14

H.L. Sham, D.A. Betebenner, W. Rosenbrook, T. Herrin, A. Saldivar, S. Vasavanonda, J.J. Plattner and D.W. Norbeck, Bioorg. Med. Chem. Lett.,14, 2643 (2004); https://doi.org/10.1016/j.bmcl.2004.02.089

A.S. Lakshmi Devi, Y.S. Rao, Y. Suresh, M.Y. Reddy, G. Jyothi, B. Rajababu, V.S. Prasad and V.U. Rao, Magn. Reson. Chem., 45, 424 (2007); https://doi.org/10.1002/mrc.1968

U. Seshachalam, B. Haribabu and K. Chandrasekhar, Biomed. Chromatogr., 21, 716 (2007); https://doi.org/10.1002/bmc.810

V.R.R. Ambati, S. Garaga, R. Dandala and S. Meenakshisunderam, Process for the Preparation of Substantially Pure (2S,3S,5S)-5-Amino2-N,N-dibenzylamino-3-hydroxy-1,6-diphenylhexane, US Patent No 8236991B (2007).

E.J. Stoner, A.J. Cooper, D.A. Dickman, L. Kolacz Kowski, J.E. Lallaman, J.H. Liu, P.A. Oliver-Shaffer, K.M. Patel, J.B. Paterson, D.J. Plata, D.A. Riley, H.L. Sham, P.J. Stengel and J.H. Tien, Org. Process Res. Dev., 4, 264 (2000);https://doi.org/10.1021/op990202j

H.L. Sham, D.W. Norbeck, X. Chen and D.A. Betebenner, Retroviral Protease Inhibiting Compounds, US Patent 5,914,332 (1995).

E. Ramu and B.V. Rao, Tetrahedron Asymm., 20, 2201 (2009); https://doi.org/10.1016/j.tetasy.2009.09.003

Issue

Vol. 33 No. 1 (2021): Vol 33 Issue 1

Synthesis and Characterization of Novel Analogues of Lopinavir

Corresponding Author(s) : Peketi Rajesh Reddy

Abstract

Keywords

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