Studies on Inclusion Complexes of &beta;-Cyclodextrin with Some Metal Complexes of Isatinylsemicarbazone and Isatinylthiosemicarbazone

Rajeev Kumar; Sanjay Kumar; Madhu Bala

doi:10.14233/ajchem.2020.22993

Issue

Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

Issue Published : December 7, 2020

This work is licensed under a Creative Commons Attribution 4.0 International License.

Studies on Inclusion Complexes of β-Cyclodextrin with Some Metal Complexes of Isatinylsemicarbazone and Isatinylthiosemicarbazone

https://doi.org/10.14233/ajchem.2020.22993

Rajeev Kumar

Department of Chemistry, Jagdam College (Affliated to Jai Prakash University, Chapra), Chapra-841301, India

Sanjay Kumar

Department of Chemistry, Jagdam College (Affliated to Jai Prakash University, Chapra), Chapra-841301, India

Madhu Bala

Department of Chemistry, R.K. Mahila College (Affliated to Binoba Bhave University, Hazaribag), Giridih-815301, India

Corresponding Author(s) : Rajeev Kumar

kumarrajeevjha258@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020
Article Published : December 7, 2020

Abstract

The complexes of Co(II), Ni(II), Zn(II) and Cd(II) with isatinylsemicarbazone (IstscabH) and isatinylthiosemicarbazone (IsttscabH) of composition ML₂·2H₂O [M = Co(II) or Ni(II) and LH = IstscabH or IsttscabH] and ML₂ [M = Zn(II) or Cd(II) and LH = IstscabH or IsttscabH] have been synthesized and their antibacterial activity has been investigated. Their inclusion complexes with β-cyclodextrin (β-CD) having composition [ML₂(β-CD)·2H₂O] or M(C₆₀H₈₈N₈O₃₉S₂)], [M = Co(II) or Ni(II) and LH = IstscabH or IsttscabH] and [ML₂(β-CD) or M(C₆₀H₈₄N₆O₃₇S₂)], [M = Zn(II) or Cd(II) and LH = IstscabH or IsttscabH] have also been isolated in solid states. All the synthesized metal complexes have been characterized by analytical data, molar conductance, magnetic susceptibility, electronic and infrared spectral studies. The tetrahedral geometry for Zn(II) and Cd(II) and octahederal geometry for Co(II) and Ni(II) have been assigned on the basis of magnetic susceptibility, UV electronic transitions and IR spectral bands assignments. The structures are retained in inclusion products. A biological activity of Schiff bases, their metal complexes and inclusion products for bacteria Escherichia coli, Bacillus subtilis and Staphylococcus aureus have been screened and activity explained.

Keywords

Isatinyl derivatives Metal complexes Inclusion β-Cyclodextrin

Kumar, R., Kumar, S., & Bala, M. (2020). Studies on Inclusion Complexes of β-Cyclodextrin with Some Metal Complexes of Isatinylsemicarbazone and Isatinylthiosemicarbazone. Asian Journal of Chemistry, 32(12), 3197–3202. https://doi.org/10.14233/ajchem.2020.22993

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T. Aboul-Fadl, F.A. Bin-Jubair and O. Aboul-Wafa, Eur. J. Med. Chem., 45, 4578 (2010); https://doi.org/10.1016/j.ejmech.2010.07.020

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M. Pal and N.K. Sharma, Int. J. Adv. Sci. Res., 2, 35 (2011).

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M. Verma, S.N. Pandeya, K.N. Singh and J.P. Stables, Acta Pharm., 54, 49 (2004).

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K. Swathi and M. Sarangapani, Asian J. Pharm. Clin. Res., 5, 197 (2012).

S.N. Pandeya, D. Sriram, P. Yogeeswari and J.P. Stables, Pharmazie, 56, 875 (2001).

F.A. Khan and A. Maalik, Trop. J. Pharm. Res., 14, 1937 (2015); https://doi.org/10.4314/tjpr.v14i10.28

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A.C. Angell, Science, 267, 1924 (1995); https://doi.org/10.1126/science.267.5206.1924

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R.K. Dubey, U.K. Dubey and S.K. Mishra, J. Coord. Chem., 64, 2292 (2011); https://doi.org/10.1080/00958972.2011.594886

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N. Kumar, P.L. Kachre and N. Kant, J. Indian Chem. Soc., 57, 98 (1980).

F.G. Baddar, O.M.M. Hilal and S. Sugden, J. Chem. Soc., 132 (1949); https://doi.org/10.1039/jr9490000132

R.S. Nyholm and B.N. Figgis, Prog. Inorg. Chem., 6, 37 (1965).

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A.B.P. Lever, Inorganic Electronic Spectroscopy, Elsevier: Amsterdam, pp. 763-791 (1968).

F.A. Cotton, D.L.M. Goodgame and M. Goodgame, J. Am. Chem. Soc., 83, 4690 (1961); https://doi.org/10.1021/ja01484a002

L.J. Bellamy, The Infrared Spectra of Complex Molecules, John Wiley & Sons, pp. 64-82 (1957).

K. Nakamoto, Infrared Spectra of Inorganic and Coordination Compounds, John Wiley: New York, edn 6, pp. 173-210 (2008).

P. Jain, D. Kumar and S. Chandra, Asian J. Chem., 31, 1 (2019); https://doi.org/10.14233/ajchem.2019.21475