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Synthesis, Characterization of Metal Complexes of Schiff Base derived from Pyrrole-2-carbaldehyde and 4-Methoxy Aniline and their Biological Studies
Corresponding Author(s) : K. Sivaraj
Asian Journal of Chemistry,
Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020
Abstract
The metal complexes of Fe(II), Co(II) and Ni(II) have been synthesized from N-((1H-pyrrol-2-yl)methylene)-4-methoxyaniline. The synthesized Schiff base and its metal complexes were structurally characterized based on IR, NMR, UV-vis spectroscopic techniques. The presence of coordinated water molecules were confirmed by thermal studies. All the synthesized compounds were screened for their antibacterial (Escherichia coli, Bacillus substilis, Salmonella typhi, Staphylococcus epidermis) and antifungal (Aspergillus flavus) and DNA cleavage activity.
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- S. Chandra, S. Parmar and Y. Kumar, Bioinorg Chem. Appl., 2009, 851316 (2009); https://doi.org/10.1155/2009/851316
- H.M. Parekh and M.N. Patel, Russ. J. Coord. Chem., 32, 431 (2006); https://doi.org/10.1134/S1070328406060066
- Z.H.A. El-Wahab and M.R. El-Sarrag, Spectrochim. Acta A Mol. Biomol. Spectrosc., 60, 271 (2004); https://doi.org/10.1016/S1386-1425(03)00216-6
- F. Firdaus, K. Fatma, M. Azam and M. Shakir, J. Coord. Chem., 63, 3956 (2010); https://doi.org/10.1080/00958972.2010.526707
- H. Keypour, M. Shayesteh, M. Rezaeivala, F. Chalabian, Y. Elerman and O. Buyukgungor, J. Mol. Struct., 1032, 62 (2013); https://doi.org/10.1016/j.molstruc.2012.07.056
- E. Abele, Main Group Met. Chem., 28, 45 (2005); https://doi.org/10.1515/MGMC.2005.28.2.45
- U. Basu, I. Pant, A. Hussain, P. Kondaiah and A.R. Chakravarty, Inorg. Chem., 54, 3748 (2015); https://doi.org/10.1021/ic5027625
- C.M. Alvarez, R. Garcia-Rodriguez and D. Miguel, Dalton Trans., 32, 3546 (2007); https://doi.org/10.1039/b702418e
- C.D. Berube, S. Gambarotta, G.P.A. Yap and P.G. Cozzi, Organometallics, 22, 434 (2003); https://doi.org/10.1021/om020773r
- T. Kawamoto, M. Nishiwaki, Y. Tsunekawa, K. Nozaki and T. Konno, Inorg. Chem., 47, 3095 (2008); https://doi.org/10.1021/ic7020758
- S. Chandra and P. Ballabh, Int. J. Pharm. Sci. Res., 4, 2393 (2013); https://doi.org/10.13040/IJPSR.0975-8232.4(6).2393-99
- R.B. Xu, N. Zhang, H.Y. Zhou, S.P. Yang, Y.Y. Li, D.H. Shi, W.X. Ma and X.X. Xu, J. Chem. Crystallogr., 42, 928 (2012); https://doi.org/10.1007/s10870-012-0338-1
- B. Lakshmi, K.N. Shivananda, G.A. Prakash, K.R.K. Rama and K.N. Mahendra, Bull. Korean Chem. Soc., 32, 1613 (2011); https://doi.org/10.5012/bkcs.2011.32.5.1613
- A.W. Bauer, W.M.M. Kirby, J.C. Sherris and M. Turck, Am. J. Clin. Pathol., 45(4_ts), 493 (1966); https://doi.org/10.1093/ajcp/45.4_ts.493
- N.G. Yernale and M.B. Hire Mathada, Bioinorg. Chem. Appl., 2014, 314963 (2014); https://doi.org/10.1155/2014/314963
- A.K. Sharma and S. Chandra, Spectrochim. Acta A Mol. Biomol. Spectrosc., 78, 337 (2011); https://doi.org/10.1016/j.saa.2010.10.017
- Z.H. Chohan, M. Arif, M.A. Akhtar and C.T. Supuran, Bioinorg. Chem. Appl., 2006, 83131 (2006); https://doi.org/10.1155/BCA/2006/83131
- R.L. Londonkar, U. Madire Kattegouga, K. Shivsharanappa and J.V. Hanchinalmath, J. Pharm. Res., 6, 280 (2013); https://doi.org/10.1016/j.jopr.2013.02.010
- NCCLS (National Committee for Clinical Laboratory Standards), Performance Standards for Antimicrobial Disc Susceptibility Test,Approved Standard M2-A6, NCCLS, Wayne, PA, USA, edn 6 (1997).
- A. Sitlani, E.C. Long, A.M. Pyle and J.K. Barton, J. Am. Chem. Soc., 114, 2303 (1992); https://doi.org/10.1021/ja00033a003
References
S. Chandra, S. Parmar and Y. Kumar, Bioinorg Chem. Appl., 2009, 851316 (2009); https://doi.org/10.1155/2009/851316
H.M. Parekh and M.N. Patel, Russ. J. Coord. Chem., 32, 431 (2006); https://doi.org/10.1134/S1070328406060066
Z.H.A. El-Wahab and M.R. El-Sarrag, Spectrochim. Acta A Mol. Biomol. Spectrosc., 60, 271 (2004); https://doi.org/10.1016/S1386-1425(03)00216-6
F. Firdaus, K. Fatma, M. Azam and M. Shakir, J. Coord. Chem., 63, 3956 (2010); https://doi.org/10.1080/00958972.2010.526707
H. Keypour, M. Shayesteh, M. Rezaeivala, F. Chalabian, Y. Elerman and O. Buyukgungor, J. Mol. Struct., 1032, 62 (2013); https://doi.org/10.1016/j.molstruc.2012.07.056
E. Abele, Main Group Met. Chem., 28, 45 (2005); https://doi.org/10.1515/MGMC.2005.28.2.45
U. Basu, I. Pant, A. Hussain, P. Kondaiah and A.R. Chakravarty, Inorg. Chem., 54, 3748 (2015); https://doi.org/10.1021/ic5027625
C.M. Alvarez, R. Garcia-Rodriguez and D. Miguel, Dalton Trans., 32, 3546 (2007); https://doi.org/10.1039/b702418e
C.D. Berube, S. Gambarotta, G.P.A. Yap and P.G. Cozzi, Organometallics, 22, 434 (2003); https://doi.org/10.1021/om020773r
T. Kawamoto, M. Nishiwaki, Y. Tsunekawa, K. Nozaki and T. Konno, Inorg. Chem., 47, 3095 (2008); https://doi.org/10.1021/ic7020758
S. Chandra and P. Ballabh, Int. J. Pharm. Sci. Res., 4, 2393 (2013); https://doi.org/10.13040/IJPSR.0975-8232.4(6).2393-99
R.B. Xu, N. Zhang, H.Y. Zhou, S.P. Yang, Y.Y. Li, D.H. Shi, W.X. Ma and X.X. Xu, J. Chem. Crystallogr., 42, 928 (2012); https://doi.org/10.1007/s10870-012-0338-1
B. Lakshmi, K.N. Shivananda, G.A. Prakash, K.R.K. Rama and K.N. Mahendra, Bull. Korean Chem. Soc., 32, 1613 (2011); https://doi.org/10.5012/bkcs.2011.32.5.1613
A.W. Bauer, W.M.M. Kirby, J.C. Sherris and M. Turck, Am. J. Clin. Pathol., 45(4_ts), 493 (1966); https://doi.org/10.1093/ajcp/45.4_ts.493
N.G. Yernale and M.B. Hire Mathada, Bioinorg. Chem. Appl., 2014, 314963 (2014); https://doi.org/10.1155/2014/314963
A.K. Sharma and S. Chandra, Spectrochim. Acta A Mol. Biomol. Spectrosc., 78, 337 (2011); https://doi.org/10.1016/j.saa.2010.10.017
Z.H. Chohan, M. Arif, M.A. Akhtar and C.T. Supuran, Bioinorg. Chem. Appl., 2006, 83131 (2006); https://doi.org/10.1155/BCA/2006/83131
R.L. Londonkar, U. Madire Kattegouga, K. Shivsharanappa and J.V. Hanchinalmath, J. Pharm. Res., 6, 280 (2013); https://doi.org/10.1016/j.jopr.2013.02.010
NCCLS (National Committee for Clinical Laboratory Standards), Performance Standards for Antimicrobial Disc Susceptibility Test,Approved Standard M2-A6, NCCLS, Wayne, PA, USA, edn 6 (1997).
A. Sitlani, E.C. Long, A.M. Pyle and J.K. Barton, J. Am. Chem. Soc., 114, 2303 (1992); https://doi.org/10.1021/ja00033a003