Diversity and Oriented Synthesis of Clopidogrel Drug Derivatives
Corresponding Author(s) : D. Tejeswararao
tejeswararao.d@gmrit.edu.in
Asian Journal of Chemistry,
Vol. 32 No. 12 (2020): Vol 32 Issue 12 page 3007-3011
Abstract
An efficient synthetic route has been developed for the synthesis of new clopidogrel drug derivatives. Key step of this method is to replacement of mesyl protected alcohol group with various aliphatic amines in presence of base. Various clopidogrel drug derivatives have been prepared in good yields. All the new compounds were confirmed by spectral studies and mass analysis. The main advantage of the new synthetic route has low cost and is fit for industrial applications.
Keywords
Clopidogrel
Antithrombotic
Antiaggregant
Antiplatelet
TejeswararaoD. (2020). Diversity and Oriented Synthesis of Clopidogrel Drug Derivatives. Asian Journal of Chemistry, 32(12), 3007-3011. Retrieved from https://asianpubs.org/index.php/ajchem/article/view/15107
Download Citation
Endnote/Zotero/Mendeley (RIS)BibTeX
References
- S.P. Lee, B.F. O’Dowd and S.R. George, Life Sci., 74, 173 (2003); https://doi.org/10.1016/j.lfs.2003.09.028
- S. Terrillon and M. Bouvier, EMBO Rep., 5, 30 (2004); https://doi.org/10.1038/sj.embor.7400052
- J.M. Rodriguez-Frade, A.J. Vila-Coro, A.M. de Ana, J.P. Albar, C. Martinez-A and M. Mellado, Proc. Natl. Acad. Sci. USA, 96, 3628 (1999); https://doi.org/10.1073/pnas.96.7.3628
- S. Angers, A. Salahpour, E. Joly, S. Hilairet, D. Chelsky, M. Dennis and M. Bouvier, Proc. Natl. Acad. Sci. USA, 97, 3684 (2000); https://doi.org/10.1073/pnas.060590697
- A. Cornea, J.A. Janovick, G. Maya-Nunez and P.M. Conn, J. Biol. Chem., 276, 2153 (2001); https://doi.org/10.1074/jbc.M007850200
- T. Wurch, A. Matsumoto and P.J. Pauwels, FEBS Lett., 507, 109 (2001); https://doi.org/10.1016/S0014-5793(01)02969-6
- R.C. Patel, U. Kumar, C. Lamb, J.S. Eid, M. Rocheville, M. Grant, A. Rani, T. Hazlett, S.C. Patel, E. Gratton and Y.C. Patel, Proc. Natl. Acad. Sci. USA, 99, 3294 (2002); https://doi.org/10.1073/pnas.042705099
- M. Hunzicker Dunn, G. Barisas, J. Song and D.A. Roess, J. Biol. Chem., 278, 42744 (2003); https://doi.org/10.1074/jbc.M306133200
- D.A. Roess and S.M. Smith, Biol. Reprod., 69, 1765 (2003); https://doi.org/10.1095/biolreprod.103.018846
- S. Gines, J. Hillion, M. Torvinen, S. Le Crom, V. Casado, E.I. Canela, S. Rondin, J.Y. Lew, S. Watson, M. Zoli, L.F. Agnati, P. Verniera, C. Lluis, S. Ferre, K. Fuxe and R. Franco, Proc. Natl. Acad. Sci. USA, 97, 8606 (2000); https://doi.org/10.1073/pnas.150241097
- M.C. Overton and K.J. Blumer, Curr. Biol., 10, 341 (2000); https://doi.org/10.1016/S0960-9822(00)00386-9
- M.A. Ayoub, C. Couturier, E. Lucas-Meunier, S. Angers, P. Fossier, M. Bouvier and R. Jockers, J. Biol. Chem., 277, 21522 (2002); https://doi.org/10.1074/jbc.M200729200
- H. Issafras, S. Angers, S. Bulenger, C. Blanpain, M. Parmentier, C. LabbeJullie, M. Bouvier and S. Marullo, J. Biol. Chem., 277, 34666 (2002); https://doi.org/10.1074/jbc.M202386200
- G.J. Babcock, M. Farzan and J. Sodroski, J. Biol. Chem., 278, 3378 (2003); https://doi.org/10.1074/jbc.M210140200
- S. Terrillon, T. Durroux, B. Mouillac, A. Breit, M.A. Ayoub, M. Taulan, R. Jockers, C. Barberis and M. Bouvier, Mol. Endocrinol., 17, 677 (2003); https://doi.org/10.1210/me.2002-0222
- F. Trettel, S. Di Bartolomeo, C. Lauro, M. Catalano, M.T. Ciotti and C. Limatola, J. Biol. Chem., 278, 40980 (2003); https://doi.org/10.1074/jbc.M306815200
- K. Simons and R. Ehehalt, J. Clin. Invest., 110, 597 (2002); https://doi.org/10.1172/JCI0216390
- K. Simons and E. Ikonen, Nature, 387, 569 (1997); https://doi.org/10.1038/42408
- L.J. Pike, J. Lipid Res., 44, 655 (2003); https://doi.org/10.1194/jlr.R200021-JLR200
- O. Cunningham, A. Andolfo, M.L. Santovito, L. Iuzzolino, F. Blasi and N. Sidenius, EMBO J., 22, 5994 (2003); https://doi.org/10.1093/emboj/cdg588
- B. Jarvis and K. Simpson, Drugs, 60, 347 (2000); https://doi.org/10.2165/00003495-200060020-00012