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Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

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Spectral Characterization, Antioxidant, Cytotoxic and Molecular Docking Studies of Nanosized Cu(II) Hybrid with 2-Hydroxyphenylethylideneamino)quinolin-2(1H)-one

https://doi.org/10.14233/ajchem.2020.22828
Murefah M. Anazy
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
Amani S. Alturiqi
Department of Chemistry, College of Science, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia
Eida S. Al-Farraj
Department of Chemistry, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), 13623, Riyadh, Saudi Arabia
Reda A. Ammar
Department of Chemistry, College of Science, Al Azhar University, Cairo, Egypt

Corresponding Author(s) : Reda A. Ammar

dr_reda06@yahoo.com

Asian Journal of Chemistry, Vol. 32 No. 12 (2020): Vol 32 Issue 12, 2020

Abstract

Nanosized Cu(II) hybrids derived 2-hydroxyphenylethylideneamino)quinolin-2(1H)-one (HPEAQ) was synthesized and characterized by spectroscopic and TGA analysis. The IR, 1H & 13C NMR spectra revealed that the HPEAQ coordinated its CH=N, C=O and deprotonated hydroxyl groups in coordination with Cu(II) ions (1-4). The geometries of copper(II) hybrids are octahedral geometry. The XRD and SEM images unequivocally definite the nanosized copper chelate (2). The antioxidant, cytotoxic activities and molecular docking technique of the compounds have also been screened.

Keywords

Nanosized Cu(II) hybrid 2-Hydroxyphenylethylideneamino)quinolin-2(1H)-one Antioxidant activity Cytotoxic activity
M. Anazy, M., S. Alturiqi, A., S. Al-Farraj, E., & A. Ammar, R. (2020). Spectral Characterization, Antioxidant, Cytotoxic and Molecular Docking Studies of Nanosized Cu(II) Hybrid with 2-Hydroxyphenylethylideneamino)quinolin-2(1H)-one. Asian Journal of Chemistry, 32(12), 2991–2996. https://doi.org/10.14233/ajchem.2020.22828
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