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Vol. 32 No. 10 (2020): Vol 32 Issue 10

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Antimicrobial and Antioxidant Activities of Diorganotin(IV) Complexes Synthesized from 1,2,4-Triazole Derivatives

https://doi.org/10.14233/ajchem.2020.22819
Jyoti Yadav
Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125001, India
Jai Devi
Department of Chemistry, Guru Jambheshwar University of Science and Technology, Hisar-125001, India

Corresponding Author(s) : Jai Devi

jaya.gju@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 10 (2020): Vol 32 Issue 10

Abstract

Novel diorganotin(IV) complexes were synthesized from 1,2,4-triazole Schiff base ligands which were synthesized by reaction between the 4-amino-5-phenyl-1,2,4-triazole-3-thiol and salicyaldehyde derivatives. The bonding and geometry of the diorganotin(IV) complexes were evaluated by using different spectroscopic techniques such as FT-IR, mass, 1H, 13C & 119Sn NMR. The different spectroscopic techniques revealed the tridentate (ONS) mode of chelation of Schiff base ligands and pentacoordinated environment around the central tin metal which was satisfied with azomethine nitrogen, phenolic oxygen, thiolic sulfur and metal-carbon bond of alkyl/aryl group. The Schiff base ligands and their organotin(IV) complexes were tested for their in vitro antimicrobial and antioxidant activities to examine the biological outline of complexes in comparison to standard drugs. The results of activities data revealed that diorganotin(IV) complexes are more active than Schiff base ligands and some diorganotin(IV) complexes are even more active than the standard drugs. In all the synthesized complexes, compound 9 (Bu2SnL2) and 10 (Ph2SnL2) were most potent and can be used in future clinical trials.

Keywords

Triazole Scavenger Chelates Antioxidant Diorganotin(IV) complexes
Yadav, J., & Devi, J. (2020). Antimicrobial and Antioxidant Activities of Diorganotin(IV) Complexes Synthesized from 1,2,4-Triazole Derivatives. Asian Journal of Chemistry, 32(10), 2553–2558. https://doi.org/10.14233/ajchem.2020.22819
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