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Vol. 32 No. 9 (2020): Vol 32 Issue 9, 2020

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Solid Phase Synthesis and Antimicrobial Activity of Novel Triazolo[1,5-a]pyrimidine Derivatives

https://doi.org/10.14233/ajchem.2020.22793%20
Shobhana A. Gadara
Department of Chemistry, Shree Manibhai Virani & Smt. Navalben Virani Science College (Autonomous), Kalawad Road, Rajkot-360005, India
Kartik D. Ladva
Department of Chemistry, Shree Manibhai Virani & Smt. Navalben Virani Science College (Autonomous), Kalawad Road, Rajkot-360005, India

Corresponding Author(s) : Shobhana A. Gadara

shobhnagadara@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 9 (2020): Vol 32 Issue 9, 2020

Abstract

A new series of triazolo[4,3-a]pyimidine derivatives via solid phase multicomponent reaction between 3-oxo-N-(4-(3-oxomorpholino)-phenyl)butanamide, aromatic aldehyde and aminoazole is reported. All the synthesized compounds have been characterized by elemental analysis and spectral analyses. Moreover, the synthesized compounds were also screened for their antibacterial activity against Staphylococcus aureus MTCC-96, Escherichia coli MTCC-443, Bacillus subtilis MTCC-441, Pseudomonas aeruginosa MTCC 1688, and antifungal activity against Aspergillus niger MTCC-282 and Penicillium sp. at different concentration and compared with standards drugs. The minimum inhibition concentration (MIC) of the compounds was studied by micro-broth dilution method.

Keywords

Aminoazole Aminoazole Antimicrobial assay Antimicrobial assay Triazolo[4,3-a]pyimidine Triazolo[4,3-a]pyimidine Solid phase multicomponent reaction Solid phase multicomponent reaction
A. Gadara, S., & D. Ladva, K. (2020). Solid Phase Synthesis and Antimicrobial Activity of Novel Triazolo[1,5-a]pyrimidine Derivatives. Asian Journal of Chemistry, 32(9), 2298–2302. https://doi.org/10.14233/ajchem.2020.22793
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