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Vol. 32 No. 9 (2020): Vol 32 Issue 9, 2020

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Design, Synthesis and Antimicrobial Evaluations of Novel 3,7-Disubstituted 2H-1-Benzopyran-2-ones

https://doi.org/10.14233/ajchem.2020.22659
Parmesh K. Dwivedi
Department of Pharmaceutical Chemistry, Amity Institute of Pharmacy, Amity University Uttar Pradesh Lucknow Campus, Lucknow-226028, India
Ashutosh Pathak
Department of Pharmacy, Maharishi University of Information Technology, Sitapur Road, IIM Bypass, Bhitauli Tiraha, Lucknow-226013, India
P. Malairajan
Department of Pharmaceutical Sciences, Sam Higginbottom University of Agriculture, Technology & Sciences, Allahabad-211007, India
Devdutt Chaturvedi
Department of Chemistry, School of Physical Sciences, Mahatma Gandhi Central University, Motihari-845401, India

Corresponding Author(s) : Parmesh K. Dwivedi

parmeshdwivedi@gmail.com

Asian Journal of Chemistry, Vol. 32 No. 9 (2020): Vol 32 Issue 9, 2020

Abstract

In present study, a novel class of 3,7-disubstituted 2H-1-benzopyran-2-one derivatives (3xa-3zc) bearing a basic ether side chain at C-7 and a substituted phenyl ring at C-3 of the coumarin ring is synthesized. These compounds have been evaluated for antimicrobial (antibacterial/antifungal) activities. Some of the compounds viz. 3xc, 3xe, 3xf, 3yb, 3yc and 3yf have shown significant antifungal activities against selective strains. Compounds 3xe, 3yb and 3yc with the MIC values of 1.56 μg/mL displayed better antifungal activity than fluconazole against Trichophyton mentagrophytes.

Keywords

Coumarins Coumarins Benzopyrans Benzopyrans Antimicrobial agents Antimicrobial agents
K. Dwivedi, P., Pathak, A., Malairajan, P., & Chaturvedi, D. (2020). Design, Synthesis and Antimicrobial Evaluations of Novel 3,7-Disubstituted 2H-1-Benzopyran-2-ones. Asian Journal of Chemistry, 32(9), 2397–2402. https://doi.org/10.14233/ajchem.2020.22659
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