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Vol. 29 No. 6 (2017): Vol 29 Issue 6

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Physico-Chemical and Analytical Study of Metoprolol Tartrate: An Antihypertensive Drug

https://doi.org/10.14233/ajchem.2017.20501
Anwar A. Wassel
Department of Chemistry, College of Science, University of Dammam, P.O. Box 1982, Dammam 31441, Saudi Arabia; National Organization for Drug Control, Research (NODCAR), Giza, Egypt
N.O. Alzamel
Department of Chemistry, College of Science, University of Dammam, P.O. Box 1982, Dammam 31441, Saudi Arabia
M.A. Alkhaldi
Department of Chemistry, College of Science, University of Dammam, P.O. Box 1982, Dammam 31441, Saudi Arabia
N. Ouerfelli
Department of Chemistry, College of Science, University of Dammam, P.O. Box 1982, Dammam 31441, Saudi Arabia; Université de Tunis El Manar, Laboratoire de Biophysique et Technologies Médicales, LR13ES07, InstitutSupérieur des Technologies Médicales de Tunis, 9 Avenue Dr. Zouhaier Essafi 1006 Tunis, Tunisia
A.A. Al-Arfaj
Department of Chemistry, College of Science, University of Dammam, P.O. Box 1982, Dammam 31441, Saudi Arabia

Corresponding Author(s) : Anwar A. Wassel

drawassel@yahoo.com

Asian Journal of Chemistry, Vol. 29 No. 6 (2017): Vol 29 Issue 6

Abstract

Metoprolol active ingredient has been investigated using X-ray diffraction analysis, thermogravimetry, differential thermal analysis, infrared and high-pressure liquid chromatography before and after exposure to 5 up to 50 kGy absorbed dose. The results obtained indicated high stability of metoprolol toward g-absorbed dose. The scheme of interaction of g-rays with metoprolol has been considered.

Keywords

X-ray IR UV HPLC g-Radiolysis Thermal stability Metoprolol
Wassel, A. A., Alzamel, N., Alkhaldi, M., Ouerfelli, N., & Al-Arfaj, A. (2017). Physico-Chemical and Analytical Study of Metoprolol Tartrate: An Antihypertensive Drug. Asian Journal of Chemistry, 29(6), 1351–1356. https://doi.org/10.14233/ajchem.2017.20501
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