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Synthesis and Antimicrobial Activity of Some New 1,2,4-Trizoles
Corresponding Author(s) : Varsha Kashaw
Asian Journal of Chemistry,
Vol. 29 No. 6 (2017): Vol 29 Issue 6
Abstract
A series of 1,2,4-triazole derivatives were synthesized using appropriate synthetic route and structures were confirmed by IR, 1H NMR and elemental analysis. All the synthesized compounds (6a-6h and 7a-7h) were evaluated for antimicrobial activity by determining their minimum inhibitory concentrations (MICs) against a panel of Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed significant antimicrobial activity against Gram-positive bacteria viz. S. aureus, B. subtilis, Gram-negative bacteria viz. E. coli, P. aerugenosa and fungi viz. C. albicans, A. niger. Some of the compounds showed better antibacterial activities against Gram-positive bacteria compared to Gram-negative bacteria. Compounds 7g, 6g, 6a exhibited good MICs against Gram-positive bacteria and 7f showed better MICs against Gram-negative bacteria compared to reference norfloxacin. Compounds 7f and 7d exhibited MICs which is equipotent to the reference drug ketoconazole.
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N. Aggarwal, R. Kumar, P. Dureja and J.M. Khurana, Eur. J. Med. Chem., 46, 4089 (2011); https://doi.org/10.1016/j.ejmech.2011.06.009.
N.D. Gaikwad, S.V. Patil and V.D. Bobade, Eur. J. Med. Chem., 54, 295 (2012); https://doi.org/10.1016/j.ejmech.2012.05.010.
S.R. Pattan, P. Gadhave, V. Tambe and D. Dengale Sand Thakur, Indian J. Chem., 51B, 297 (2012).
R. Diwedi, S. Alexander and M.J.N. Chandrasekar, Res. J. Pharm. Biol. Chem. Sci., 2, 194 (2011).
A.M. Vijesh, A.M. Isloor, P. Shetty, S. Sundershan and H.K. Fun, Eur. J. Med. Chem., 62, 410 (2013); https://doi.org/10.1016/j.ejmech.2012.12.057.
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